The application of marine polysaccharides to antitumor nanocarriers
文献类型：期刊论文
| 作者 | Wang, Hui1,2,3 ; Hunter, Roger4; Zhang, Quanbin1,3; Yu, Haoyu1,2,3; Wang, Jing1,3; Yue, Yang1; Geng, Lihua1; Wu, Ning1,2,3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2024-10-15 |
| 卷号 | 342页码:13 |
| 关键词 | Fucoidan Chitosan Alginate Carrageenan Porphyran Antitumor nanocarriers |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.122407 |
| 通讯作者 | Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Nanotechnology has revolutionized the diagnosis, monitoring and treatment of biomedical diseases, in which nanocarriers have greatly improved the targeting and bioavailability of antitumor drugs. The marine natural polysaccharides fucoidan, chitosan, alginate, carrageenan and porphyran have broad-spectrum bioactivities and unique physicochemical properties such as excellent non-toxicity, biocompatibility, biodegradability and reproducibility, which have placed them as a principal focus in the nanocarrier field. Nanocarriers based on different types of marine polysaccharides are distinctive in addressing antitumor therapeutic challenges such as targeting, environmental responsiveness, drug resistance, tissue toxicity, enhancing diagnostic imaging, overcoming the first-pass effect and innovative 3D binding. Additionally, they all share the possibility of relatively easy chemical modification, while their separation into well-defined derivatives provide innovative structureactivity relationship possibilities. Liposomes, nanoparticles and polymer-micelles constructed from them can efficiently deliver drugs such as paclitaxel, gemcitabine, siRNA and others, which are widely used in radiotherapy, chemotherapy, immunotherapy, nucleic acid therapy and photothermal therapy, yet there are still infinite possibilities for innovation and exploration. This article reviews the recent advances and challenges of marine polysaccharide-based delivery systems as oncology drug nanocarriers. |
| WOS关键词 | CANCER-TREATMENT ; NANOPARTICLES ; STATISTICS ; FUCOIDAN ; CELLS ; ULVAN ; ACID |
| 资助项目 | National Natural Science Foundation of China[42176137] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001259695900001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186410]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Ning |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Dept Drugs & Bioprod, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Cape Town, Chem Dept, ZA-7701 Cape Town, South Africa |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Hunter, Roger,Zhang, Quanbin,et al. The application of marine polysaccharides to antitumor nanocarriers[J]. CARBOHYDRATE POLYMERS,2024,342:13. |
| APA | Wang, Hui.,Hunter, Roger.,Zhang, Quanbin.,Yu, Haoyu.,Wang, Jing.,...&Wu, Ning.(2024).The application of marine polysaccharides to antitumor nanocarriers.CARBOHYDRATE POLYMERS,342,13. |
| MLA | Wang, Hui,et al."The application of marine polysaccharides to antitumor nanocarriers".CARBOHYDRATE POLYMERS 342(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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