Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops
文献类型：期刊论文
| 作者 | Lin, Zhuo-Ru1,2 ; Geng, Hui-Xia2; Yu, Ren-Cheng1,2,3
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2024-05-05 |
| 卷号 | 469页码:13 |
| 关键词 | Gymnodinium catenatum Argopecten irradians Paralytic shellfish poisoning GC toxins |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2024.133896 |
| 通讯作者 | Yu, Ren-Cheng(rcyu@qdio.ac.cn) |
| 英文摘要 | Paralytic shellfish toxins (PSTs) produced by some marine dinoflagellates can cause severe human intoxication via vectors like bivalves. Toxic dinoflagellate Gymnodinium catenatum produce a novel group of hydroxybenzoate PSTs named GC toxins, but their biokinetics in bivalves haven't been well examined. In this experiment, we analyzed PSTs in bay scallops Argopecten irradians exposed to G. catenatum (strain MEL11) to determine their accumulation, elimination, anatomical distribution, and biotransformation. To our surprise, up to 30% of the PSTs were accumulated in the adductor muscle of scallops at the end of the experiment, and the toxicity of adductor muscle exceeded the regulatory limit of 800 mu g STXeq/kg in only 6 days. High concentration of toxins in the adductor muscle are likely linked to the rapid transfer of GC toxins from viscera to other tissues. Moreover, most GC toxins in scallops were found rapidly transformed to decarbamoyl toxins through enzyme-mediated hydrolysis, which was further supported by the in vitro incubation experiments. Our study demonstrates that GC toxins actively participate in toxin distribution and transformation in scallops, which may increase the risks of food poisoning associated with the consumption of scallop adductor muscle. Environmental implication: The negative impacts of harmful algal blooms (HABs) have become a global environmental concern under the joint effects of cultural eutrophication and climate change. Our study, targeted on |
| WOS关键词 | GYMNODINIUM-CATENATUM GRAHAM ; LIQUID-CHROMATOGRAPHY ; PSP TOXINS ; ARGOPECTEN-VENTRICOSUS ; SAXITOXIN ANALOGS ; POISONING TOXINS ; MEXICAN PACIFIC ; DINOFLAGELLATE ; MUSSEL ; BIOTRANSFORMATION |
| 资助项目 | National Key Research and Development (R & D) Programs of China[2022YFC3105200] ; National Key Research and Development (R & D) Programs of China[2017YFC1600701] ; Pilot National Laboratory for Marine Science and Technology (Qingdao)[LSKJ202203700] ; Taishan Scholars Program of Professor Ren-cheng Yu |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001210925400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/185640]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Yu, Ren-Cheng |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Zhuo-Ru,Geng, Hui-Xia,Yu, Ren-Cheng. Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,469:13. |
| APA | Lin, Zhuo-Ru,Geng, Hui-Xia,&Yu, Ren-Cheng.(2024).Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops.JOURNAL OF HAZARDOUS MATERIALS,469,13. |
| MLA | Lin, Zhuo-Ru,et al."Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops".JOURNAL OF HAZARDOUS MATERIALS 469(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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