MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species
文献类型：期刊论文
| 作者 | Wang, Chaogang3,4,5,6 ; Du, Mingyang3,4,5,6; Jiang, Zhuxiang3,4,5,6; Cong, Rihao2,4,5,6,8,9; Wang, Wei2,5,6,7,8,9; Zhang, Taiping3,4,5,6; Chen, Jincheng3,4,5,6; Zhang, Guofan1,2,4,5,6,8,9; Li, Li1,2,3,5,6,7,8
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| 刊名 | ISCIENCE
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| 出版日期 | 2024-07-19 |
| 卷号 | 27期号:7页码:22 |
| DOI | 10.1016/j.isci.2024.110321 |
| 通讯作者 | Li, Li(lili@qdio.ac.cn) |
| 英文摘要 | Pyruvate kinase (PK), as a key rate-limiting enzyme in glycolysis, has been widely used to assess the stress tolerance and sensitivity of organisms. However, its phosphorylation regulatory mechanisms mainly focused on human cancer research, with no reports in marine organisms. In this study, we firstly reported a conserved PK Ser11 phosphorylation site in mollusks, which enhanced enzyme activity by promoting substrate binding, thereby regulating divergent thermal metabolism of two allopatric congeneric oyster species with differential habitat temperature. It was phosphorylated by ERK kinase, and regulated by the classical MAPK pathway. The MAPK/ERK-PK signaling cascade responded to increased environmental temperature and exhibited stronger activation pattern in the relatively thermotolerant species ( Crassos- trea angulata ), indicating its involvement in shaping temperature adaptation. These findings highlight the presence of complex and unique phosphorylation-mediated signaling transduction mechanisms in marine organisms, and provide new insights into the evolution and function of the crosstalk between classical pathways. |
| WOS关键词 | MYTILUS-GALLOPROVINCIALIS ; PYRUVATE-KINASE ; HEAT-STRESS ; PROTEIN EXPRESSION ; OXIDATIVE STRESS ; PHOSPHORYLATION ; RESPONSES ; PKM2 ; CARBOHYDRATE ; ACTIVATION |
| 资助项目 | National Key R&D Program of China[2022YFD2400304] ; Key Research and Development Program of Shandong[2022LZGC015] ; Key Research and Development Program of Shandong[ZFJH202309] ; National Natural Science Foundation of China[32101353] ; Young Elite Scientists Sponsorship Program by China Association of Science and Technology[2021QNRC001] ; China Agriculture Research System of MOF and MARA[CARS-49] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001266278500001 |
| 出版者 | CELL PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186320]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China 2.Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 6.Chinese Acad Sci, Qingdao, Peoples R China 7.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Shandong, Peoples R China 8.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 9.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chaogang,Du, Mingyang,Jiang, Zhuxiang,et al. MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species[J]. ISCIENCE,2024,27(7):22. |
| APA | Wang, Chaogang.,Du, Mingyang.,Jiang, Zhuxiang.,Cong, Rihao.,Wang, Wei.,...&Li, Li.(2024).MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species.ISCIENCE,27(7),22. |
| MLA | Wang, Chaogang,et al."MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species".ISCIENCE 27.7(2024):22. |
入库方式： OAI收割
来源：海洋研究所
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