中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 海洋生态与环境科学重点实验室
Integrated transcriptomic and metabolomic approaches reveal molecular response and potential biomarkers of the deep-sea mussel Gigantidas platifrons to copper exposure

文献类型：期刊论文

作者He, Yameng3; Zhou, Li3; Wang, Minxiao3; Zhong, Zhaoshan3; Chen, Hao3; Lian, Chao3; Zhang, Huan3; Wang, Hao3; Cao, Lei3; Li, Chaolun1,2,3,4,5
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2024-07-15
卷号473页码:13
关键词Mytilidae Deep-sea Metals Multi-omics Toxic effects Biomarkers
ISSN号0304-3894
DOI10.1016/j.jhazmat.2024.134612
通讯作者Zhou, Li(lizhou@qdio.ac.cn) ; Li, Chaolun(lcl@qdio.ac.cn)
英文摘要Metal pollution caused by deep-sea mining activities has potential detrimental effects on deep-sea ecosystems. However, our knowledge of how deep-sea organisms respond to this pollution is limited, given the challenges of remoteness and technology. To address this, we conducted a toxicity experiment by using deep-sea mussel Gigantidas platifrons as model animals and exposing them to different copper (Cu) concentrations (50 and 500 mu g/ L) for 7 days. Transcriptomics and LC-MS-based metabolomics methods were employed to characterize the profiles of transcription and metabolism in deep-sea mussels exposed to Cu. Transcriptomic results suggested that Cu toxicity significantly affected the immune response, apoptosis, and signaling processes in G. platifrons. Metabolomic results demonstrated that Cu exposure disrupted its carbohydrate metabolism, anaerobic meta- bolism and amino acid metabolism. By integrating both sets of results, transcriptomic and metabolomic, we find that Cu exposure significantly disrupts the metabolic pathway of protein digestion and absorption in G. platifrons . Furthermore, several key genes (e.g., heat shock protein 70 and baculoviral IAP repeat -containing protein 2/3) and metabolites (e.g., alanine and succinate) were identified as potential molecular biomarkers for deep-sea mussel 's responses to Cu toxicity. This study contributes novel insight for assessing the potential effects of deep-sea mining activities on deep-sea organisms.
WOS关键词BATHYMODIOLUS-AZORICUS ; RUDITAPES-PHILIPPINARUM ; ANAEROBIC METABOLISM ; METAL CONTAMINATION ; GENE-EXPRESSION ; CADMIUM ; STRESS ; SIGNAL ; INVERTEBRATES ; MECHANISMS
资助项目National Key R&D Program of China[2022YFC2804003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42020401] ; National Natural Science Foundation of China[42276153] ; National Natural Science Foundation of China[42030407] ; Key Research Program of Frontier Sciences, CAS[ZDBS-LY-DQC032] ; State Key Laboratory of Microcbial Technology Open Projects Fund[M2023-10]
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001243332700001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/186596]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Zhou, Li; Li, Chaolun
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Laoshan Lab, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Deep Sea Res, Inst Oceanol, Qingdao 266071, Peoples R China
4.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
5.Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
推荐引用方式
GB/T 7714		 He, Yameng,Zhou, Li,Wang, Minxiao,et al. Integrated transcriptomic and metabolomic approaches reveal molecular response and potential biomarkers of the deep-sea mussel Gigantidas platifrons to copper exposure[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,473:13.
APA He, Yameng.,Zhou, Li.,Wang, Minxiao.,Zhong, Zhaoshan.,Chen, Hao.,...&Li, Chaolun.(2024).Integrated transcriptomic and metabolomic approaches reveal molecular response and potential biomarkers of the deep-sea mussel Gigantidas platifrons to copper exposure.JOURNAL OF HAZARDOUS MATERIALS,473,13.
MLA He, Yameng,et al."Integrated transcriptomic and metabolomic approaches reveal molecular response and potential biomarkers of the deep-sea mussel Gigantidas platifrons to copper exposure".JOURNAL OF HAZARDOUS MATERIALS 473(2024):13.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。