Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells
文献类型：期刊论文
| 作者 | Wang, Jie2,3; Li, Ping3; Zhang, Renshuai3; Zhang, Miao3; Wang, Chao3; Zhao, Kaihua1; Wang, Jing2; Wang, Ning2; Xing, Dongming3 |
| 刊名 | SMALL
 |
| 出版日期 | 2024-07-05 |
| 页码 | 12 |
| 关键词 | coarse grained molecular dynamics flexibility nanoparticle-cell affinity surface chemistry ultrathin silica nanosheets |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202401772 |
| 通讯作者 | Wang, Jie(wangj91@qdu.edu.cn) ; Wang, Ning(wangning@qdio.ac.cn) ; Xing, Dongming(xdm@qdu.edu.cn) |
| 英文摘要 | Flexibility of nanomaterials is challenging but worthy to tune for biomedical applications. Biocompatible silica nanomaterials are under extensive exploration but are rarely observed to exhibit flexibility despite the polymeric nature. Herein, a facile one-step route is reported to ultrathin flexible silica nanosheets (NSs), whose low thickness and high diameter-to-thickness ratio enables folding. Thickness and diameter can be readily tuned to enable controlled flexibility. Mechanism study reveals that beyond the commonly used surfactant, the "uncommon" one bearing two hydrophobic tails play a guiding role in producing sheeted/layered/shelled structures, while addition of ethanol appropriately relieved the strong interfacial tension of the assembled surfactants, which will otherwise produce large curled sheeted structures. With these ultrathin NSs, it is further shown that the cellular preference for particle shape and rigidity is highly dependent on surface chemistry of nanoparticles: under high particle-cell affinity, NSs, and especially the flexible ones will be preferred by mammalian cells for internalization or attachment, while this preference is basically invalid when the affinity is low. Therefore, properties of the ultrathin silica NSs can be effectively expanded and empowered by surface chemistry to realize improved bio-sensing or drug delivery. Via a co-templating and interfacial tension-tuned approach, ultrathin silica nanosheets showing high and tunable flexibility are fabricated, with surface chemistry-modulated interaction with mammalian cells. image |
| WOS关键词 | NANOPARTICLES ; SPHERES ; GROWTH |
| 资助项目 | Natural Science Foundation of Shandong Province[ZR2023QC090] ; China Postdoctoral Science Foundation[2021T140355] ; National Natural Science Foundation of China[82303590] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001262345900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/186317]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Wang, Jie; Wang, Ning; Xing, Dongming |
| 作者单位 | 1.Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Dept Breast Surg, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jie,Li, Ping,Zhang, Renshuai,et al. Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells[J]. SMALL,2024:12. |
| APA | Wang, Jie.,Li, Ping.,Zhang, Renshuai.,Zhang, Miao.,Wang, Chao.,...&Xing, Dongming.(2024).Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells.SMALL,12. |
| MLA | Wang, Jie,et al."Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells".SMALL (2024):12. |
入库方式： OAI收割
来源：海洋研究所
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