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Targeted mitigation of neointimal hyperplasia via magnetic field-directed localization of superparamagnetic iron oxide nanoparticle-labeled endothelial progenitor cells following carotid balloon catheter injury in rats

文献类型：期刊论文

作者Li, Zhongxuan1,2; Zhang, Yingqian1; Ma, Mingrui2; Wang, Wei1; Hui, Hui3,4,5,9; Tian, Jie3,4,6,7,8,9; Chen, Yundai1
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2024-08-01
卷号177页码:13
关键词Endothelial progenitor cells Magnetic targeting SPIONs Neointimal hyperplasia Magnetic particle imaging
ISSN号0753-3322
DOI10.1016/j.biopha.2024.117022
通讯作者Hui, Hui(hui.hui@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Chen, Yundai(chenyundai@301hospital.com.cn)
英文摘要Background: The transplantation of endothelial progenitor cells (EPCs) has been shown to reduce neointimal hyperplasia following arterial injury. However, the efficacy of this approach is hampered by limited homing of EPCs to the injury site. Additionally, the in vivo recruitment and metabolic activity of transplanted EPCs have not been continuously monitored. Methods: EPCs were labeled with indocyanine green (ICG)-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) and subjected to external magnetic field targeting to enhance their delivery to a carotid balloon injury (BI) model in Sprague-Dawley rats. Magnetic particle imaging (MPI)/ fluorescence imaging (FLI) multimodal in vivo imaging, 3D MPI/CT imaging and MPI/FLI ex vivo imaging was performed after injury. Carotid arteries were collected and analyzed for pathology and immunofluorescence staining. The paracrine effects were analyzed by enzyme-linked immunosorbent assay. Results: The application of a magnetic field significantly enhanced the localization and retention of SPIONs@PEG-ICG-EPCs at the site of arterial injury, as evidenced by both in vivo continuous monitoring and ex vivo by observation. This targeted delivery approach effectively inhibited neointimal hyperplasia and increased the presence of CD31-positive cells at the injury site. Moreover, serum levels of SDF-1 alpha, VEGF, IGF-1, and TGF-beta 1 were significantly elevated, indicating enhanced paracrine activity. Conclusions: Our findings demonstrate that external magnetic field-directed delivery of SPIONs@PEG-ICG-EPCs to areas of arterial injury can significantly enhance their therapeutic efficacy. This enhancement is likely mediated through increased paracrine signaling. These results underscore the potential of magnetically guided SPIONs@PEG-ICG-EPCs delivery as a promising strategy for treating arterial injuries.
WOS关键词CORONARY-ARTERY-DISEASE ; STEM-CELLS ; GOLD NANOPARTICLES ; VASCULAR INJURY ; ELUTING STENT ; ANGIOGENESIS ; DELIVERY ; CONTRIBUTE ; STRATEGY ; MODULATE
资助项目National Natural Science Foundation of China[U23A6011] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[92359304] ; Beijing Natural Science Foundation[JQ22023] ; CAS Youth Innova-tion Promotion Association[Y2022055]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001259725100001
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Youth Innova-tion Promotion Association
源URL[http://ir.ia.ac.cn/handle/173211/59163]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hui, Hui; Tian, Jie; Chen, Yundai
作者单位1.Peoples Liberat Army Gen Hosp, Sixth Med Ctr, Sr Dept Cardiol, Beijing 100853, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Beijing 100853, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
6.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China
7.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
8.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing 100191, Peoples R China
9.Natl Key Lab Kidney Dis, Beijing 100853, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zhongxuan,Zhang, Yingqian,Ma, Mingrui,et al. Targeted mitigation of neointimal hyperplasia via magnetic field-directed localization of superparamagnetic iron oxide nanoparticle-labeled endothelial progenitor cells following carotid balloon catheter injury in rats[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,177:13.
APA Li, Zhongxuan.,Zhang, Yingqian.,Ma, Mingrui.,Wang, Wei.,Hui, Hui.,...&Chen, Yundai.(2024).Targeted mitigation of neointimal hyperplasia via magnetic field-directed localization of superparamagnetic iron oxide nanoparticle-labeled endothelial progenitor cells following carotid balloon catheter injury in rats.BIOMEDICINE & PHARMACOTHERAPY,177,13.
MLA Li, Zhongxuan,et al."Targeted mitigation of neointimal hyperplasia via magnetic field-directed localization of superparamagnetic iron oxide nanoparticle-labeled endothelial progenitor cells following carotid balloon catheter injury in rats".BIOMEDICINE & PHARMACOTHERAPY 177(2024):13.

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来源：自动化研究所

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