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Near-infrared II fl uorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy

文献类型：期刊论文

作者Zhao, Hongyang1,2,3,4; Li, Chunzhao2,5,6; Shi, Xiaojing2,7; Zhang, Jinnan1,3,4; Jia, Xiaohua2; Hu, Zhenhua2,7,8; Gao, Yufei1,3,4; Tian, Jie2,7,8,9
刊名EBIOMEDICINE
出版日期2024-08-01
卷号106页码:15
关键词Glioma Monocarboxylate transporter 4 Near-infrared window II Fluorescent molecular imaging Photothermal therapy
ISSN号2352-3964
DOI10.1016/j.ebiom.2024.105243
通讯作者Jia, Xiaohua(xiaohua.jia@ia.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Gao, Yufei(gaoyf@jlu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Background Surgery is crucial for glioma treatment, but achieving complete tumour removal remains challenging. We evaluated the effectiveness of a probe targeting monocarboxylate transporter 4 (MCT4) in recognising gliomas, and of near-infrared window II (NIR-II) fl uorescent molecular imaging and photothermal therapy as treatment strategies. Methods We combined an MCT4-speci fi c monoclonal antibody with indocyanine green to create the probe. An orthotopic mouse model and a transwell model were used to evaluate its ability to guide tumour resection using NIR-II fl uorescence and to penetrate the blood - brain barrier (BBB), respectively. A subcutaneous tumour model was established to con fi rm photothermal therapy eff i cacy. Probe speci fi city was assessed in brain tissue from mice and humans. Finally, probe effectiveness in photothermal therapy was investigated. Findings MCT4 was differentially expressed in tumour and normal brain tissue. The designed probe exhibited precise tumour targeting. Tumour imaging was precise, with a signal-to-background (SBR) ratio of 2.8. Residual tumour cells were absent from brain tissue postoperatively (SBR: 6.3). The probe exhibited robust penetration of the BBB. Moreover, the probe increased the tumour temperature to 50 degrees C within 5 min of laser excitation. Photothermal therapy signi fi cantly reduced tumour volume and extended survival time in mice without damage to vital organs. Interpretation These fi ndings highlight the potential eff i cacy of our probe for fl uorescence-guided surgery and therapeutic interventions.
WOS关键词EXPRESSION ; 1ST-IN-HUMAN ; RECOGNITION ; RESECTION ; LACTATE ; GLIOMAS ; MCT1
资助项目Jilin Province Department of Science and Technology[20200403079SF] ; Department of Finance[2021SCZ06] ; National Natural Science Foundation of China[92059207] ; National Natural Science Foundation of China[92359301] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[U21A20386] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Development and Reform Commission[20200601002JC]
WOS研究方向General & Internal Medicine ; Research & Experimental Medicine
语种英语
WOS记录号WOS:001269257000001
出版者ELSEVIER
资助机构Jilin Province Department of Science and Technology ; Department of Finance ; National Natural Science Foundation of China ; CAS Youth Interdisciplinary Team ; Development and Reform Commission
源URL[http://ir.ia.ac.cn/handle/173211/59236]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Jia, Xiaohua; Hu, Zhenhua; Gao, Yufei; Tian, Jie
作者单位1.Jilin Univ, China Japan Union Hosp, Dept Neurosurg, 126 Xiantai St, Changchun 130033, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
3.Jilin Prov Neurooncol Engn Lab, Changchun, Peoples R China
4.Jilin Prov Key Lab Neurooncol, Changchun, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
6.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
8.Natl Key Lab Kidney Dis, Beijing, Peoples R China
9.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Hongyang,Li, Chunzhao,Shi, Xiaojing,et al. Near-infrared II fl uorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy[J]. EBIOMEDICINE,2024,106:15.
APA Zhao, Hongyang.,Li, Chunzhao.,Shi, Xiaojing.,Zhang, Jinnan.,Jia, Xiaohua.,...&Tian, Jie.(2024).Near-infrared II fl uorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy.EBIOMEDICINE,106,15.
MLA Zhao, Hongyang,et al."Near-infrared II fl uorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy".EBIOMEDICINE 106(2024):15.

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来源：自动化研究所

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