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A Novel Local Magnetic Fluid Hyperthermia Based on High Gradient Field Guided by Magnetic Particle Imaging

文献类型：期刊论文

作者Lei, Siao1,2,3,4; He, Jie1,2,3,4; Huang, Xiazi3; Hui, Hui4,5; An, Yu1,2,3,4; Tian, Jie1,2,3,4
刊名IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
出版日期2024-08-01
卷号71期号:8页码:2528-2536
关键词Magnetic particle imaging magnetic fluid hyperthermia high gradient field Magnetic particle imaging magnetic fluid hyperthermia high gradient field
ISSN号0018-9294
DOI10.1109/TBME.2024.3378650
通讯作者An, Yu(yuan1989@buaa.edu.cn) ; Tian, Jie(tian@ieee.org)
英文摘要Magnetic Particle Imaging (MPI)-guided Magnetic Fluid Hyperthermia (MFH) has the potential for widespread utilization, as it allows for the prediction of magnetothermal dosage, real-time visualization of the thermal therapy process, and precise localization of the lesion area. However, the existing MPI-guided MFH (MPI-MFH) method is insensitive to concentration gradients of magnetic nanoparticles (MNPs) and is susceptible to causing damage to normal tissues with high MNP concentrations during MFH treatment, while inadequately heating tumor tissues with lower MNP concentrations. In this work, we established a relationship between MNP concentration and heating efficiency through simulations and phantom measurements, enabling the optimal selection of MFH parameters guided by MPI. Based on these findings, we developed a high-gradient field MPI-MFH method using a field-free point (FFP) approach to achieve precise local heating. Phantom experiments and in vivo glioma model experiments were conducted to validate this proposed method. The results demonstrated that the proposed method of MPI-MFH can improve the MNP concentration gradient sensitivity to +/- 1 mg/ml, thereby enabling more effective lesion-site heating without damaging normal tissues. This method not only reduced glioma size effectively but also holds promise for application in various other types of cancers.
WOS关键词PLATFORM
资助项目National Key Research and Development Program of China[2023YFC3402800] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; Beijing Natural Science Foundation[JQ22023] ; Beijing Natural Science Foundation[L232097] ; CAS Youth Innovation Promotion Association[Y2022055] ; CAS Key Technology Talent Program
WOS研究方向Engineering
语种英语
WOS记录号WOS:001273933600004
出版者IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program
源URL[http://ir.ia.ac.cn/handle/173211/59352]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者An, Yu; Tian, Jie
作者单位1.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China
2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
3.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China
5.Hong Kong Polytech Univ, Dept Biomed Engn, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Lei, Siao,He, Jie,Huang, Xiazi,et al. A Novel Local Magnetic Fluid Hyperthermia Based on High Gradient Field Guided by Magnetic Particle Imaging[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2024,71(8):2528-2536.
APA Lei, Siao,He, Jie,Huang, Xiazi,Hui, Hui,An, Yu,&Tian, Jie.(2024).A Novel Local Magnetic Fluid Hyperthermia Based on High Gradient Field Guided by Magnetic Particle Imaging.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,71(8),2528-2536.
MLA Lei, Siao,et al."A Novel Local Magnetic Fluid Hyperthermia Based on High Gradient Field Guided by Magnetic Particle Imaging".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 71.8(2024):2528-2536.

入库方式： OAI收割

来源：自动化研究所

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