Contributions of repeated learning to memory in humans: insights from single-neuron recordings in the hippocampus and amygdala
文献类型：期刊论文
| 作者 | Xiao, Xinyu1,2 ; Li, Jin3; Cao, Dan2; Zhang, Jiaqi1,2; Jiang, Tianzi1,2,4,5,6
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2024-06-10 |
| 卷号 | 34期号:6页码:9 |
| 关键词 | repeated learning single-neuron recordings representational similarity analysis hippocampus amygdala |
| ISSN号 | 1047-3211 |
| DOI | 10.1093/cercor/bhae244 |
| 通讯作者 | Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) |
| 英文摘要 | Despite the well-established phenomenon of improved memory performance through repeated learning, studies investigating the associated neural mechanisms have yielded complex and sometimes contradictory findings, and direct evidence from human neuronal recordings has been lacking. This study employs single-neuron recordings with exceptional spatial-temporal resolution, combined with representational similarity analysis, to explore the neural dynamics within the hippocampus and amygdala during repeated learning. Our results demonstrate that in the hippocampus, repetition enhances both representational specificity and fidelity, with these features predicting learning times. Conversely, the amygdala exhibits heightened representational specificity and fidelity during initial learning but does not show improvement with repetition, suggesting functional specialization of the hippocampus and amygdala during different stages of the learning repetition. Specifically, the hippocampus appears to contribute to sustained engagement necessary for benefiting from repeated learning, while the amygdala may play a role in the representation of novel items. These findings contribute to a comprehensive understanding of the intricate interplay between these brain regions in memory processes.Significance statement For over a century, understanding how repetition contributes to memory enhancement has captivated researchers, yet direct neuronal evidence has been lacking, with a primary focus on the hippocampus and a neglect of the neighboring amygdala. Employing advanced single-neuron recordings and analytical techniques, this study unveils a nuanced functional specialization within the amygdala-hippocampal circuit during various learning repetition. The results highlight the hippocampus's role in sustaining engagement for improved memory with repetition, contrasting with the amygdala's superior ability in representing novel items. This exploration not only deepens our comprehension of memory enhancement intricacies but also sheds light on potential interventions to optimize learning and memory processes. |
| WOS关键词 | PATTERN SEPARATION ; REPRESENTATIONS ; SIMILARITY |
| 资助项目 | STI2030-Major Projects[2021ZD0200200] ; National Natural Science Foundation of China[32271085] ; National Natural Science Foundation of China[62327805] ; Key Research Project of Zhejiang Lab[2022KI0AC02] ; Key Research Project of Zhejiang Lab[2022ND0AN01] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001242388200004 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | STI2030-Major Projects ; National Natural Science Foundation of China ; Key Research Project of Zhejiang Lab |
| 源URL | [http://ir.ia.ac.cn/handle/173211/58670]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Jiang, Tianzi |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Tianzi Jiang Brainnetome Ctr, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 3.Capital Normal Univ, Sch Psychol, Beijing 100048, Peoples R China 4.Res Ctr Augmented Intelligence, Zhejiang Lab, Hangzhou 311100, Peoples R China 5.Xiaoxiang Inst Brain Hlth, Yongzhou 425000, Hunan, Peoples R China 6.Yongzhou Cent Hosp, Yongzhou 425000, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Xinyu,Li, Jin,Cao, Dan,et al. Contributions of repeated learning to memory in humans: insights from single-neuron recordings in the hippocampus and amygdala[J]. CEREBRAL CORTEX,2024,34(6):9. |
| APA | Xiao, Xinyu,Li, Jin,Cao, Dan,Zhang, Jiaqi,&Jiang, Tianzi.(2024).Contributions of repeated learning to memory in humans: insights from single-neuron recordings in the hippocampus and amygdala.CEREBRAL CORTEX,34(6),9. |
| MLA | Xiao, Xinyu,et al."Contributions of repeated learning to memory in humans: insights from single-neuron recordings in the hippocampus and amygdala".CEREBRAL CORTEX 34.6(2024):9. |
入库方式： OAI收割
来源：自动化研究所
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