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Model-predicted brain temperature computational imaging by multimodal noninvasive functional neuromonitoring of cerebral oxygen metabolism and hemodynamics: MRI-derived and clinical validation

文献类型：期刊论文

作者Jiang, Miaowen1; Cao, Fuzhi2; Zhang, Qihan3; Qi, Zhengfei1; Gao, Yuan2; Zhang, Yang3; Song, Baoyin3; Wu, Chuanjie3; Li, Ming4,5; Xu, Yongbo6
刊名JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
出版日期2024-08-11
页码17
关键词Brain temperature imaging cerebral oxygen metabolism hemodynamics model-predicted MRI-derived
ISSN号0271-678X
DOI10.1177/0271678X241270485
通讯作者Wang, Yuan(wilma0106@163.com) ; Wei, Ming(drweiming@163.com) ; Ji, Xunming(jixm@ccmu.edu.cn)
英文摘要Brain temperature, a crucial yet under-researched neurophysiological parameter, is governed by the equilibrium between cerebral oxygen metabolism and hemodynamics. Therapeutic hypothermia has been demonstrated as an effective intervention for acute brain injuries, enhancing survival rates and prognosis. The success of this treatment hinges on the precise regulation of brain temperature. However, the absence of comprehensive brain temperature monitoring methods during therapy, combined with a limited understanding of human brain heat transmission mechanisms, significantly hampers the advancement of hypothermia-based neuroprotective therapies. Leveraging the principles of bioheat transfer and MRI technology, this study conducted quantitative analyses of brain heat transfer during mild hypothermia therapy. Utilizing MRI, we reconstructed brain structures, estimated cerebral blood flow and oxygen consumption parameters, and developed a brain temperature calculation model founded on bioheat transfer theory. Employing computational cerebral hemodynamic simulation analysis, we established an intracranial arterial fluid dynamics model to predict brain temperature variations across different therapeutic hypothermia modalities. We introduce a noninvasive, spatially resolved, and optimized mathematical bio-heat model that synergizes model-predicted and MRI-derived data for brain temperature prediction and imaging. Our findings reveal that the brain temperature images generated by our model reflect distinct spatial variations across individual participants, aligning with experimentally observed temperatures.
WOS关键词THERAPEUTIC HYPOTHERMIA ; THEORETICAL-MODEL ; THERMOMETRY ; CALIBRATION ; INFARCTION ; DESIGN ; SYSTEM
资助项目Beijing Municipal Natural Science Foundation[7244510] ; National Natural Science Foundation of China[82102220] ; National Natural Science Foundation of China[82027802] ; National Natural Science Foundation of China[61975017] ; Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission[Z221100007422023] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support from Yangfan Project[YGLX202325] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical[2023-JKCS-09] ; Beijing Association for Science and Technology Youth Talent Support Program[BYESS2022081]
WOS研究方向Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:001288885900001
出版者SAGE PUBLICATIONS INC
资助机构Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China ; Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support from Yangfan Project ; Non-profit Central Research Institute Fund of Chinese Academy of Medical ; Beijing Association for Science and Technology Youth Talent Support Program
源URL[http://ir.ia.ac.cn/handle/173211/59300]  
专题自动化研究所_脑网络组研究中心
通讯作者Wang, Yuan; Wei, Ming; Ji, Xunming
作者单位1.Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
2.Beihang Univ, Sch Engn Med, Beijing 100083, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Neurol & Neurosurg, Beijing 100053, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Beijing Inst Geriatr, Beijing 100053, Peoples R China
6.Tianjin Med Univ, Clin Coll Neurol Neurosurg & Neurorehabil, Tianjin 300203, Peoples R China
7.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Lab Brain Atlas & Brain Inspired Intelligence, Beijing 100190, Peoples R China
8.Tianjin Univ, Tianjin Huanhu Hosp, Tianjin 300203, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Miaowen,Cao, Fuzhi,Zhang, Qihan,et al. Model-predicted brain temperature computational imaging by multimodal noninvasive functional neuromonitoring of cerebral oxygen metabolism and hemodynamics: MRI-derived and clinical validation[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2024:17.
APA Jiang, Miaowen.,Cao, Fuzhi.,Zhang, Qihan.,Qi, Zhengfei.,Gao, Yuan.,...&Ji, Xunming.(2024).Model-predicted brain temperature computational imaging by multimodal noninvasive functional neuromonitoring of cerebral oxygen metabolism and hemodynamics: MRI-derived and clinical validation.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,17.
MLA Jiang, Miaowen,et al."Model-predicted brain temperature computational imaging by multimodal noninvasive functional neuromonitoring of cerebral oxygen metabolism and hemodynamics: MRI-derived and clinical validation".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2024):17.

入库方式： OAI收割

来源：自动化研究所

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