Inflammation in Steatotic Liver Diseases: Pathogenesis and Therapeutic Targets
文献类型：期刊论文
| 作者 | Qian, Shengying2,3; Wang, Xiaolin1; Chen, Yingfen2,3; Zai, Qiuhong2,3; He, Yong2,3 |
| 刊名 | SEMINARS IN LIVER DISEASE
 |
| 出版日期 | 2024-06-25 |
| 页码 | 14 |
| 关键词 | ALD MASLD macrophages neutrophils single-cell RNA sequencing |
| ISSN号 | 0272-8087 |
| DOI | 10.1055/a-2338-9261 |
| 通讯作者 | He, Yong(heyong@simm.ac.cn) |
| 英文摘要 | Alcohol-related liver disease (ALD) and metabolic dysfunction-associated steatotic liverdisease (MASLD), two main types of steatotic liver disease (SLDs), are characterized by awide spectrum of several different liver disorders, including simple steatosis, steatohepa-titis,cirrhosis,and hepatocellularcarcinoma .Multiple immune cell-mediated inflammatory responses not only orchestrate the killing and removal of infected/damaged cells but alsoexacerbate the development of SLDs when excessive or persistent inflammation occurs. Inrecent years,single-cellandspatialtranscriptomeanalyseshaverevealedtheheterogeneityof liver-infiltrated immune cells in ALD and MASLD, revealing a new immunopathologicalpicture ofSLDs.Inthisreview,we will emphasize theroles of several key immune cells in the pathogenesis of ALD and MASLD and discuss inflammation-based approaches for effectiveSLD intervention. In conclusion, the study of immunological mechanisms, especially highly specific immune cell population functions, may provide novel therapeutico pportunities forthis life-threatening disease |
| WOS关键词 | INSULIN-RESISTANCE ; T-CELLS ; MACROPHAGES ; LANDSCAPE ; FIBROSIS ; NASH ; STEATOHEPATITIS ; NEUTROPHILS ; CROSSTALK ; DISTINCT |
| 资助项目 | National Key Research and Development Program of China[2023YFA1800804] ; Natural Science Foundation of China[82270601] ; Natural Science Foundation of China[82270596] ; Natural Science Foundation of Shanghai[22ZR1473800] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:001253521100001 |
| 出版者 | THIEME MEDICAL PUBL INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312020]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | He, Yong |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Infect Dis, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Shengying,Wang, Xiaolin,Chen, Yingfen,et al. Inflammation in Steatotic Liver Diseases: Pathogenesis and Therapeutic Targets[J]. SEMINARS IN LIVER DISEASE,2024:14. |
| APA | Qian, Shengying,Wang, Xiaolin,Chen, Yingfen,Zai, Qiuhong,&He, Yong.(2024).Inflammation in Steatotic Liver Diseases: Pathogenesis and Therapeutic Targets.SEMINARS IN LIVER DISEASE,14. |
| MLA | Qian, Shengying,et al."Inflammation in Steatotic Liver Diseases: Pathogenesis and Therapeutic Targets".SEMINARS IN LIVER DISEASE (2024):14. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。