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The glycyl-l-histidyl-l-lysine-Cu 2+tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6

文献类型：期刊论文

作者Bian, Yiding3,4,5,6,7,8; Deng, Mingming4,5,6,7,8; Liu, Jia2; Li, Jiaye4,5,6,7,8; Zhang, Qin4,5,6,7,8; Wang, Zilin3,4,5,6,7,8; Liao, Liwei4,5,6,7,8; Miao, Jinrui4,5,6,7,8; Li, Ruixia4,5,6,7,8; Zhou, Xiaoming1
刊名REDOX BIOLOGY
出版日期2024-09-01
卷号75页码:8
关键词Silicosis GHK-Cu Oxidative stress Macrophage PRDX6
ISSN号2213-2317
DOI10.1016/j.redox.2024.103237
通讯作者Zhou, Xiaoming(zhouxmcmu@163.com) ; Hou, Gang(hougangcmu@163.com)
英文摘要Silicosis is the most common type of pneumoconiosis, having a high incidence in workers chronically exposed to crystalline silica (CS). No specific medication exists for this condition. GHK, a tripeptide naturally occurring in human blood and urine, has antioxidant effects. We aimed to investigate the therapeutic effect of GHK-Cu on silicosis and its potential underlying molecular mechanism. An experimental silicosis mouse model was established to observe the effects of GHK-Cu on lung inflammation and fibrosis. Moreover, the effects of GHK-Cu on the alveolar macrophages (AM) were examined using the RAW264.7 cell line. Its molecular target, peroxiredoxin 6 (PRDX6), has been identified, and GHK-Cu can bind to PRDX6, thus attenuating lung inflammation and fibrosis in silicosis mice without significant systemic toxicity. These effects were partly related to the inhibition of the CSinduced oxidative stress in AM induced by GHK-Cu. Thus, our results suggest that GHK-Cu acts as a potential drug by attenuating alveolar macrophage oxidative stress. This, in turn, attenuates the progression of pulmonary inflammation and fibrosis, which provides a reference for the treatment of silicosis.
WOS关键词INHIBITION ; EXPOSURE ; GHK
资助项目National High Level Hospital Clinical Research Funding[2022-NHLHCRF-LX-01] ; National Natural Sci- ence Foundation of China[82300053] ; China Postdoctoral Science Foundation[2023M733987] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Science[2020-PT320- 005]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:001258537400001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/312023]  
专题中国科学院上海药物研究所
通讯作者Zhou, Xiaoming; Hou, Gang
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Dept Pulm & Crit Care Med,Dis, Beijing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China
4.China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
5.Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China
6.Chinese Acad Med Sci, Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China
7.Chinese Acad Med Sci, State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China
8.Chinese Acad Med Sci, Natl Ctr Resp Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Bian, Yiding,Deng, Mingming,Liu, Jia,et al. The glycyl-l-histidyl-l-lysine-Cu 2+tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6[J]. REDOX BIOLOGY,2024,75:8.
APA Bian, Yiding.,Deng, Mingming.,Liu, Jia.,Li, Jiaye.,Zhang, Qin.,...&Hou, Gang.(2024).The glycyl-l-histidyl-l-lysine-Cu 2+tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.REDOX BIOLOGY,75,8.
MLA Bian, Yiding,et al."The glycyl-l-histidyl-l-lysine-Cu 2+tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6".REDOX BIOLOGY 75(2024):8.

入库方式： OAI收割

来源：上海药物研究所

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