Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer's disease
文献类型：期刊论文
| 作者 | Zhang, Xiaolin7; He, Guiqin7; Hu, Yixuan5,6; Liu, Boren4; Xu, Yuliang4; Li, Xia3; Lv, Xinyou2; Li, Jin1,7 |
| 刊名 | IMMUNITY & AGEING
 |
| 出版日期 | 2024-06-25 |
| 卷号 | 21期号:1页码:12 |
| 关键词 | Alzheimer's disease Neutrophils Single cell RNA sequencing CCRL2 |
| ISSN号 | 1742-4933 |
| DOI | 10.1186/s12979-024-00448-x |
| 通讯作者 | Lv, Xinyou(xinyoulv@ustc.edu.cn) ; Li, Jin(lijin_2021@163.com) |
| 英文摘要 | BackgroundNeutrophils play an essential role in Alzheimer's disease (AD) pathology. However, the extent of their heterogeneity remains poorly explored, particularly in the context of developing novel therapies targeting these cells.ResultsWe investigate the population structure of neutrophils purified from peripheral blood samples of AD mice. Utilizing single cell RNA sequencing, we comprehensively map neutrophil populations into six distinct clusters and find that the Neu-5 subset is specially enriched in AD mice. This subset exhibits fewer specific granules and a lower mature score. Gene ontology (GO) analysis reveals that genes involved in cytokine-mediated signaling are downregulated in the Neu-5 cluster. Furthermore, we identify the Ccrl2 gene is specifically upregulated in this subgroup, which is confirmed by flow cytometry in AD mice. Finally, immunohistochemical staining indicates that CCRL2 protein is increased in the brains of AD mice.ConclusionsWe identify a unique CCRL2 positive neutrophil cluster, that is specifically enriched in the peripheral blood of AD mice. |
| WOS关键词 | GENE-EXPRESSION ; TAU ; PATHOLOGY ; RECEPTOR ; BRAINS ; CCRL2 |
| 资助项目 | National Natural Science Foundation of China[82104151] ; National Natural Science Foundation of China[82101565] ; National Natural Science Foundation of China[82201566] ; Shanghai Sailing Program[21YF1439500] ; Shanghai Sailing Program[22YF1439300] |
| WOS研究方向 | Geriatrics & Gerontology ; Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:001254153900001 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312032]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lv, Xinyou; Li, Jin |
| 作者单位 | 1.Univ Sci & Technol China, Inst Publ Hlth Sci, Div Life Sci & Med, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Humanities & Social Sci, Dept Psychol, Hefei 230026, Anhui, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China 4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Med, Natl Ctr Mental Disorders, Brain Hlth Inst,Shanghai Mental Hlth Ctr,Shanghai, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaolin,He, Guiqin,Hu, Yixuan,et al. Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer's disease[J]. IMMUNITY & AGEING,2024,21(1):12. |
| APA | Zhang, Xiaolin.,He, Guiqin.,Hu, Yixuan.,Liu, Boren.,Xu, Yuliang.,...&Li, Jin.(2024).Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer's disease.IMMUNITY & AGEING,21(1),12. |
| MLA | Zhang, Xiaolin,et al."Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer's disease".IMMUNITY & AGEING 21.1(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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