Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity
文献类型：期刊论文
| 作者 | Wen, Xueping2; Song, Yufei2; Zhang, Mei1 ; Kang, Yiping1; Chen, Dandan1; Ma, Hui1; Nan, Fajun1; Duan, Yanan1; Li, Jingya1,2
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| 刊名 | BIOMOLECULES
 |
| 出版日期 | 2024-06-01 |
| 卷号 | 14期号:6页码:21 |
| 关键词 | 18a adipocytes polyphenols thermogenesis UCP1 |
| DOI | 10.3390/biom14060618 |
| 通讯作者 | Duan, Yanan(duanyanan@simm.ac.cn) ; Li, Jingya(jyli@simm.ac.cn) |
| 英文摘要 | Recent studies increasingly suggest that targeting brown/beige adipose tissues to enhance energy expenditure offers a novel therapeutic approach for treating metabolic diseases. Brown/beige adipocytes exhibit elevated expression of uncoupling protein 1 (UCP1), which is a thermogenic protein that efficiently converts energy into heat, particularly in response to cold stimulation. Polyphenols possess potential anti-obesity properties, but their pharmacological effects are limited by their bioavailability and distribution within tissue. This study discovered 18a, a polyphenol compound with a favorable distribution within adipose tissues, which transcriptionally activates UCP1, thereby promoting thermogenesis and enhancing mitochondrial respiration in brown adipocytes. Furthermore, in vivo studies demonstrated that 18a prevents high-fat-diet-induced weight gain and improves insulin sensitivity. Our research provides strong mechanistic evidence that UCP1 is a complex mediator of 18a-induced thermogenesis, which is a critical process in obesity mitigation. Brown adipose thermogenesis is triggered by 18a via the AMPK-PGC-1 alpha pathway. As a result, our research highlights a thermogenic controlled polyphenol compound 18a and clarifies its underlying mechanisms, thus offering a potential strategy for the thermogenic targeting of adipose tissue to reduce the incidence of obesity and its related metabolic problems. |
| WOS关键词 | FISETIN IMPROVES BIOAVAILABILITY ; ACTIVATED PROTEIN-KINASE ; BROWN ADIPOSE-TISSUE ; MITOCHONDRIAL-FUNCTION ; RESVERATROL ; AMPK ; FAT ; UCP1 ; FORMULATION ; EXPRESSION |
| 资助项目 | Shanghai Science and Technology Development Funds[23YF1407900] ; Program of Shanghai Academic Research Leader[22XD1400600] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001254619000001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312035]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Duan, Yanan; Li, Jingya |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 189 Guo Shou Jing Rd, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Xueping,Song, Yufei,Zhang, Mei,et al. Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity[J]. BIOMOLECULES,2024,14(6):21. |
| APA | Wen, Xueping.,Song, Yufei.,Zhang, Mei.,Kang, Yiping.,Chen, Dandan.,...&Li, Jingya.(2024).Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity.BIOMOLECULES,14(6),21. |
| MLA | Wen, Xueping,et al."Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity".BIOMOLECULES 14.6(2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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