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ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing

文献类型：期刊论文

作者Li, Lijun2,3; Wang, Ying2,3; Xu, Yuqi2,3; Xu, Jian2,3; Zhao, Yanqi2,3; Cheng, Zijian2,3; Fang, Yuelin1; Miao, Yunqiu3; Zhang, Xinxin1,2,3
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2024-07-01
卷号371页码:298-312
关键词Liquid crystalline nanoparticles Extracellular vesicles Wound healing Mesenchymal stem cells ROS scavenging Inflammation alleviation
ISSN号0168-3659
DOI10.1016/j.jconrel.2024.05.048
通讯作者Zhang, Xinxin(xinxinzhang@simm.ac.cn)
英文摘要Wound management is a critical clinical challenge due to the dynamic and complex pathological characteristics of inflammation, proliferation, and matrix remodeling. To address this challenge, the regulation and management of this multi-stage pathological microenvironment may provide a feasible approach to wound healing. In this work, we synthesized a new lipid material (DA) with reactive oxygen species (ROS) scavenging effect to prepare DA-based liquid crystalline (DALC). Then, DALC was incorporated with adipose mesenchymal stem cellsderived extracellular vesicles (AMSC-EVs) to fabricate a novel scaffold dressing (EVs@DALC) for the treatment of the wound. DALC not only endowed EVs@DALC with ROS scavenging sites for relieving the oxidative stress and inflammation in the microenvironment of the wound site, but also facilitated cellular uptake and transfection of microRNA and growth factors contained in AMSC-EVs. Benefiting from DALC, AMSC-EVs effectively transferred microRNA and growth factors into the skin cells to induce cell proliferation and migration and accelerate angiogenesis. The results of wound healing effect in vivo indicate EVs@DALC achieved multi-stage pathological modulation for accelerating wound healing through alleviating inflammation, promoting cell proliferation and migration, and angiogenesis. Taken together, this work provides an effective strategy based on antioxidant lipid liquid crystalline delivering extracellular vesicles in treating skin wounds and paves a way for stem cell extracellular vesicles clinical translation.
WOS关键词EXOSOMES ; NANOPARTICLE ; PATHWAY
资助项目National Natural Science Foundation of China[82222066] ; National Natural Science Foundation of China[82104113] ; National Key Research and Development Program of China[2022YFC2304104] ; Natural Science Foundation of Shanghai[21ZR1475800] ; Chinese Pharmacopoeia Commission[2021Y19] ; Chinese Pharmacopoeia Commission[2022Y30]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001254091300001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/312047]  
专题新药研究国家重点实验室
通讯作者Zhang, Xinxin
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lijun,Wang, Ying,Xu, Yuqi,et al. ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing[J]. JOURNAL OF CONTROLLED RELEASE,2024,371:298-312.
APA Li, Lijun.,Wang, Ying.,Xu, Yuqi.,Xu, Jian.,Zhao, Yanqi.,...&Zhang, Xinxin.(2024).ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing.JOURNAL OF CONTROLLED RELEASE,371,298-312.
MLA Li, Lijun,et al."ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing".JOURNAL OF CONTROLLED RELEASE 371(2024):298-312.

入库方式： OAI收割

来源：上海药物研究所

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