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  4. 新药研究国家重点实验室
Germacrane-type sesquiterpenes from Pilea cavaleriei Levl. subsp. cavaleriei

文献类型：期刊论文

作者Huang, Wanyu4,5,6; Ke, Chang-Qiang4,5; Feng, Zheling4,5; Yao, Sheng2,3,4,5; Tang, Chunping4,5; Ye, Yang1,4,5,6
刊名FITOTERAPIA
出版日期2024-09-01
卷号177页码:9
关键词Pilea cavaleriei Levl. subsp. cavaleriei Cavalinols A -K Germacrane type DFT NMR calculation TDDFT ECD calculation
ISSN号0367-326X
DOI10.1016/j.fitote.2024.106008
通讯作者Tang, Chunping() ; Ye, Yang(yye@simm.ac.cn)
英文摘要The first systematic investigation of germacrane-type sesquiterpenes from Pilea cavaleriei Levl. subsp. cavaleriei was conducted. Eleven undescribed germacrane analogues named cavalinols A-K were identified. Their planar structures were determined by extensive analysis of 1D and 2D NMR spectroscopic data, and the absolute configurations were further determined by X-ray single crystal diffraction, Mosher method, and time dependent density functional theory (TDDFT) electron circular dichroism (ECD) calculation, with the aid from DFT NMR calculation and NOESY experiment. Except for the common 10-memebered ring, ten new compounds contained a p-coumaroyl sidechain connected to C-8 of the nucleus skeleton. All the isolated compounds were screened for anti-inflammatory activity in LPS stimulated RAW 264.7 cells, and compounds 5 and 6 showed moderate activity.
资助项目National Natural Science Foundation of China[21920102003] ; Key -Area Research and Development Program of Guangdong Province[2020B0303070002] ; National Key Research and Development Program Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001259037800001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/312107]  
专题新药研究国家重点实验室
通讯作者Tang, Chunping; Ye, Yang
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Wanyu,Ke, Chang-Qiang,Feng, Zheling,et al. Germacrane-type sesquiterpenes from Pilea cavaleriei Levl. subsp. cavaleriei[J]. FITOTERAPIA,2024,177:9.
APA Huang, Wanyu,Ke, Chang-Qiang,Feng, Zheling,Yao, Sheng,Tang, Chunping,&Ye, Yang.(2024).Germacrane-type sesquiterpenes from Pilea cavaleriei Levl. subsp. cavaleriei.FITOTERAPIA,177,9.
MLA Huang, Wanyu,et al."Germacrane-type sesquiterpenes from Pilea cavaleriei Levl. subsp. cavaleriei".FITOTERAPIA 177(2024):9.

入库方式： OAI收割

来源：上海药物研究所

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