Recent progress on the organelle targeted AlEgens for bioimaging and treatment of diseases
文献类型：期刊论文
| 作者 | Ding, Qihang5,6,7; Luo, Yan7; Hu, Jun4; Zhang, Shuai3; Zhang, Wenzhe6,7; Feng, Yuanyuan6,7; Qian, Kun2; Li, Xin7; Cheng, Zhen1,2; Gu, Meijia6,7 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2024-09-01 |
| 卷号 | 495页码:18 |
| 关键词 | Aggregation -induced emission Organelles -targeting Bioimaging The second near -infrared window Phototheranostics |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2024.153395 |
| 通讯作者 | Li, Xin(xin.li@whu.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) ; Gu, Meijia(mjgu@whu.edu.cn) |
| 英文摘要 | The organelles within cells perform distinct functions, regulating various physiological activities. Simultaneously, they collaboratively engage in intricate connections to execute essential physiological processes crucial for the organism's survival. Therefore, the development of fluorescent probes capable of accurately targeting organelles at the subcellular level holds significant importance. Additionally, facilitating biological imaging and treatment of diseases of these specific organelles is crucial. Aggregation-induced emission luminogens (AIEgens), with their counteractive nature to the aggregation-caused quenching (ACQ) effect, exhibit strong fluorescence emission rates, exceptional photostability, and high signal-to-noise ratios. These attributes make them highly attractive as noninvasive real-time fluorescence imaging tools, and their applications in disease treatment are currently undergoing extensive exploration. This review consolidates recent research progress on AIEgens, focusing on organelle-targeted fluorescence imaging. Furthermore, an exploration into the application of AIEgens for disease diagnosis and treatment is conducted. The overarching objective of this review is to provide insight into future prospects and enlighten novel ideas for the application of AIEgens in the context of various diseases. |
| WOS关键词 | AGGREGATION-INDUCED EMISSION ; ENDOPLASMIC-RETICULUM ; OXIDATIVE STRESS ; MITOCHONDRIA ; LYSOSOME ; NUCLEUS ; PROBES ; AIEGEN ; PHOTOSENSITIZERS ; VISUALIZATION |
| 资助项目 | National Natural Science Foundation of China[62332006] ; National Natural Science Foundation of China[62172302] ; National Natural Science Foundation of China[U2267221] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001261861600001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312116]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xin; Cheng, Zhen; Gu, Meijia |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Harbin Med Univ, Canc Hosp, Dept Med Oncol, 150 Haping Rd, Harbin 150040, Heilongjiang, Peoples R China 4.Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Wuhan 430071, Hubei, Peoples R China 5.Korea Univ, Dept Chem, Seoul 02841, South Korea 6.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China 7.Wuhan Univ, Dept Gynecol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Qihang,Luo, Yan,Hu, Jun,et al. Recent progress on the organelle targeted AlEgens for bioimaging and treatment of diseases[J]. CHEMICAL ENGINEERING JOURNAL,2024,495:18. |
| APA | Ding, Qihang.,Luo, Yan.,Hu, Jun.,Zhang, Shuai.,Zhang, Wenzhe.,...&Gu, Meijia.(2024).Recent progress on the organelle targeted AlEgens for bioimaging and treatment of diseases.CHEMICAL ENGINEERING JOURNAL,495,18. |
| MLA | Ding, Qihang,et al."Recent progress on the organelle targeted AlEgens for bioimaging and treatment of diseases".CHEMICAL ENGINEERING JOURNAL 495(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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