Pharmacodynamical research of extracts and compounds in traditional Chinese medicines for Parkinson's disease
文献类型：期刊论文
| 作者 | Li, Mengmeng1,2; Wang, Hanze1,2; Bai, Yuxin1,2; Xiong, Fuyu1,2; Wu, Shifei1; Bi, Qirui1; Qiao, Yajun1; Zhang, Yan1,2; Li, Xiaolan1; Feng, Lin1,2 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-09-01 |
| 卷号 | 177页码:11 |
| 关键词 | Parkinson's disease Traditional Chinese medicine Mechanism of action |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.106086 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease (AD). Currently, there is no cure for PD, and medications can only control the progression of the disease. Various experimental studies have shown the significant efficacy of TCM in treating PD, and combination with western medicine can enhance the effects and reduce toxicity. Thus, exploring effective anti-PD compounds from TCM has become a popular research fields. This review summarizes commonly used TCM extracts and natural products for the treatment of PD, both domestically and internationally. Furthermore, it delves into various mechanisms of TCM in treating PD, such as anti-oxidative stress, anti-inflammatory, anti-apoptotic, improve mitochondrial dysfunction, inhibits alpha-synuclein (alpha-Syn) misfolding and aggregation, regulating neurotransmitters, regulates intestinal flora, enhances immunity, and so on. The results reveal that most TCMs exert their neuroprotective effects through anti-inflammatory and anti-oxidative stress actions, thereby slowing down the progression of the disease. These TCM may hold the key to improving PD therapy and have tremendous potential to be developed as novel anti-PD drugs. |
| WOS关键词 | RAT MODEL ; MITOCHONDRIAL DYSFUNCTION ; DOPAMINERGIC-NEURONS ; OXIDATIVE STRESS ; PROTOCATECHUIC ACID ; PC12 CELLS ; NEUROTOXICITY ; INHIBITION ; ACTIVATION ; MPTP |
| 资助项目 | Qi-Huang Chief Scientist Program of National Administration of Traditional Chinese Medicine |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001261538600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312122]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China 2.Changchun Univ Chinese Med, Coll Pharmaceut Sci, Changchun 130117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mengmeng,Wang, Hanze,Bai, Yuxin,et al. Pharmacodynamical research of extracts and compounds in traditional Chinese medicines for Parkinson's disease[J]. FITOTERAPIA,2024,177:11. |
| APA | Li, Mengmeng.,Wang, Hanze.,Bai, Yuxin.,Xiong, Fuyu.,Wu, Shifei.,...&Guo, De-an.(2024).Pharmacodynamical research of extracts and compounds in traditional Chinese medicines for Parkinson's disease.FITOTERAPIA,177,11. |
| MLA | Li, Mengmeng,et al."Pharmacodynamical research of extracts and compounds in traditional Chinese medicines for Parkinson's disease".FITOTERAPIA 177(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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