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Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy

文献类型：期刊论文

作者Liang, Li8,9,10; Wang, Ning7,8,9; Li, Xiang7,8,9; Zhang, Zhuan8,9,10; Zhu, Zhu5,8,9; Zhuo, Yan8,9; Jiang, Xiaohe7,8,9; Wang, Jie4,8,9; Guo, Cong7,8,9; Guo, Shiyan8,9
刊名NANO TODAY
出版日期2024-08-01
卷号57页码:15
关键词Exosomes Shape Intracellular trafficking ER-Targeted drug delivery Anticancer therapy
ISSN号1748-0132
DOI10.1016/j.nantod.2024.102377
通讯作者Zhu, Yan(zhuyan1992521@163.com) ; Gan, Yong(ygan@simm.ac.cn) ; Yu, Miaorong(mryu@simm.ac.cn)
英文摘要Exosomes are nanoscale extracellular vesicles that have become pivotal in advancing targeted drug delivery strategies for cancer therapy. In this study, we conducted a comparative analysis of the intracellular targeting capabilities of differently shaped exosomes, including milk exosome nanorods (MR), ginger exosome nanorods (GR), and cancer cell exosome nanorods (HR), compared to their spherical counterparts. Our observations revealed that exosome nanorods demonstrated effective and sustained targeting of the endoplasmic reticulum (ER) within cancer cells, while exosome nanospheres were captured within lysosomes. Building on this principle, we chose milk-derived exosomes (mExo) for the in vivo research, engineering the surface of MR with folate to enhance their tumor-targeting efficacy. We demonstrated the effective accumulation of these folate-modified MR (FMR) around the ER in cancer cells, as validated in both orthotopic colorectal cancer (CRC) tissues and human CRC biopsy samples. Furthermore, when loaded with curcumin (Cur), the FMR@Cur exhibited remarkable efficacy in suppressing tumors in orthotopic CRC mouse models. This effect is attributed to the targeted delivery of FMR@Cur to the ER, leading to enhanced ER-stress induced apoptosis. Overall, our study underscores the pivotal role of shape engineering in exosome-mediated drug delivery, offering novel insights and paving the way for innovative strategies to enhance the precision of intracellular drug targeting in cancer therapy.
WOS关键词EXTRACELLULAR VESICLES ; TUMOR ; NANOPARTICLES ; STRATEGIES ; THERAPY
资助项目National Science Fund of Distinguished Young Scholars[82025032] ; National Natural Science Foundation of China[82073773] ; National Natural Science Foundation of China[82104078] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ- TLC005] ; Young Elite Scientists Sponsorship Program by CAST[2022QNRC001]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001260014500001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/312140]  
专题新药研究国家重点实验室
通讯作者Zhu, Yan; Gan, Yong; Yu, Miaorong
作者单位1.Shanghai Collaborat Innovat Ctr Endoscopy, Shanghai 201203, Peoples R China
2.Fudan Univ, Zhongshan Hosp, Endoscopy Res Inst, Shanghai 201203, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Endoscopy Ctr, Shanghai 201203, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
5.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China
6.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
9.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
10.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Liang, Li,Wang, Ning,Li, Xiang,et al. Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy[J]. NANO TODAY,2024,57:15.
APA Liang, Li.,Wang, Ning.,Li, Xiang.,Zhang, Zhuan.,Zhu, Zhu.,...&Yu, Miaorong.(2024).Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy.NANO TODAY,57,15.
MLA Liang, Li,et al."Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy".NANO TODAY 57(2024):15.

入库方式： OAI收割

来源：上海药物研究所

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