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Nature Products Chlorophyll Derivatives for NIR-II Fluorescence Bioimaging and Plant-Imaging

文献类型：期刊论文

作者Chen, Kaixin4,5,6; Shi, Hui4,5; Li, Lei4,5,6; Yang, Mao3; Qian, Kun4,5; Xu, Wen2; Qu, Chunrong4,5; Cheng, Zhen1,4,5
刊名CHEMISTRY-A EUROPEAN JOURNAL
出版日期2024-07-02
页码10
关键词NIR-II Chlorophyll Imaging Nature product
ISSN号0947-6539
DOI10.1002/chem.202401805
通讯作者Xu, Wen(ZN001877@whu.edu.cn) ; Qu, Chunrong(crqu@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn)
英文摘要The second near-infrared window (NIR-II, 1000-1700 nm) fluorescence imaging has attracted significant attention in research fields because of its unique advantages compared with conventional optical windows (400-900 nm). A variety of NIR-II fluorophores have been actively studied because they serve as a key component of fluorescence imaging. Among them, organic small molecule NIR-II fluorophores display outstanding imaging performance and many advantages, but types of small molecule NIR-II fluorophores with high biocompatibility are still quite limited. Novel molecular scaffolds based NIR-II dyes are highly desired. Herein, we hypothesized that chlorophyll is a new promising molecular platform for discovery NIR-II fluorophores. Thus, seven derivatives of derivatives were selected to characterize their optical properties. Interestingly, six chlorophyll derivatives displayed NIR-II fluorescence imaging capability. This characteristic allowed the successful NIR-II imaging of green leaves of various plants. Furthermore, most of these fluorophores showed capacity to monitor viscosity change because of their sensitive for viscosity. For demonstration of its biomedical applications, these probes were successfully used for NIR-II fluorescence-guided surgical resection of lymph nodes. In summary, chlorophylls are novel valuable tool molecules for NIR-II fluorescence imaging and have potential to expand their applications in biomedical field and plant science. Chlorophyll, the most well-known natural product, has applications in a variety of fields, and we have applied it to NIR-II imaging for the first time, and the results show that it has great potential in plant and biological research. image
WOS关键词BLOOD-VISCOSITY ; QUANTUM YIELD ; PROBES ; DYE
资助项目National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[81901799] ; Shanghai Municipal Science and Technology Major Project[TM202301H003] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Science and Technology Major Project of Gansu province[23ZDFA014]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001259648600001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/312143]  
专题新药研究国家重点实验室
通讯作者Xu, Wen; Qu, Chunrong; Cheng, Zhen
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Wuhan Univ, Dept Pediat, Zhongnan Hosp, Wuhan 430071, Peoples R China
3.Macau Univ Sci & Technol, Ave WaiLong, Taipa 999078, Macau, Peoples R China
4.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.Nanjing Univ Chinese Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Kaixin,Shi, Hui,Li, Lei,et al. Nature Products Chlorophyll Derivatives for NIR-II Fluorescence Bioimaging and Plant-Imaging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2024:10.
APA Chen, Kaixin.,Shi, Hui.,Li, Lei.,Yang, Mao.,Qian, Kun.,...&Cheng, Zhen.(2024).Nature Products Chlorophyll Derivatives for NIR-II Fluorescence Bioimaging and Plant-Imaging.CHEMISTRY-A EUROPEAN JOURNAL,10.
MLA Chen, Kaixin,et al."Nature Products Chlorophyll Derivatives for NIR-II Fluorescence Bioimaging and Plant-Imaging".CHEMISTRY-A EUROPEAN JOURNAL (2024):10.

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来源：上海药物研究所

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