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New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease

文献类型：期刊论文

作者Zhang, Jinming4; Li, Yixin3; Yang, Liu1,2; Ma, Ningning1,2; Qian, Shengying1,2; Chen, Yingfen1,2; Duan, Yajun3; Xiang, Xiaogang4; He, Yong1,2
刊名CELL AND BIOSCIENCE
出版日期2024-07-06
卷号14期号:1页码:18
关键词MASLD ALD T2DM Metabolic disorder Drug candidate
DOI10.1186/s13578-024-01267-9
通讯作者Duan, Yajun(yajunduan@ustc.edu.cn) ; Xiang, Xiaogang(shine-xxg@163.com) ; He, Yong(heyong@simm.ac.cn)
英文摘要Metabolic disorders are currently threatening public health worldwide. Discovering new targets and developing promising drugs will reduce the global metabolic-related disease burden. Metabolic disorders primarily consist of lipid and glucose metabolic disorders. Specifically, metabolic dysfunction-associated steatosis liver disease (MASLD) and alcohol-associated liver disease (ALD) are two representative lipid metabolism disorders, while diabetes mellitus is a typical glucose metabolism disorder. In this review, we aimed to summarize the new drug candidates with promising efficacy identified in clinical trials for these diseases. These drug candidates may provide alternatives for patients with metabolic disorders and advance the progress of drug discovery for the large disease burden.
WOS关键词NONALCOHOLIC FATTY LIVER ; STEAROYL-COA DESATURASE-1 ; FARNESOID-X-RECEPTOR ; COLONY-STIMULATING FACTOR ; PLACEBO-CONTROLLED TRIAL ; PPAR-GAMMA ; BILE-ACIDS ; INSULIN SENSITIVITY ; OBETICHOLIC ACID ; HEPATOCELLULAR-CARCINOMA
资助项目Natural Science Foundation of China[82270601] ; National Key Research and Development Program of China[2023YFA1800804] ; Natural Science Foundation of Shanghai[22ZR1473800]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:001263389000001
出版者BMC
源URL[http://119.78.100.183/handle/2S10ELR8/312234]  
专题中国科学院上海药物研究所
通讯作者Duan, Yajun; Xiang, Xiaogang; He, Yong
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China
3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Cardiol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Infect Dis, Sch Med, Shanghai 200025, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jinming,Li, Yixin,Yang, Liu,et al. New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease[J]. CELL AND BIOSCIENCE,2024,14(1):18.
APA Zhang, Jinming.,Li, Yixin.,Yang, Liu.,Ma, Ningning.,Qian, Shengying.,...&He, Yong.(2024).New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease.CELL AND BIOSCIENCE,14(1),18.
MLA Zhang, Jinming,et al."New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease".CELL AND BIOSCIENCE 14.1(2024):18.

入库方式： OAI收割

来源：上海药物研究所

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