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Alginate/silk fibroin/Zn 2+composite microspheres for site-specific delivery for enhanced ulcerative colitis therapy

文献类型：期刊论文

作者Du, Yaoyao4,5; Jiang, Yuting4,5; Song, Yijie5; Chen, Jie4,5; Wu, Yueqian4,5; Guo, Ru4,5; He, Yihao4,5; Shen, Lan5; Wang, Bing4; Huang, Shaogang2
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2024-09-01
卷号495页码:13
关键词Ulcerative colitis Colon targeting Oral hydrogel microsphere Intestinal barrier repair
ISSN号1385-8947
DOI10.1016/j.cej.2024.153441
通讯作者Shen, Lan(alansusu@sina.com) ; Wang, Bing(bwang@simm.ac.cn) ; Huan, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要The limited therapeutic efficacy of oral medications against ulcerative colitis (UC) is attributed to inadequate drug exposure to inflammation site in the colon. To address this challenge, we developed a pH-triggered oral hydrogel microsphere system composed of alginate/silk fibroin (Alg/SF) using zinc ions (Zn2+) as a crosslink agent for colon-targeted delivery. This system, with moderate gelation toughness, can protect the antiinflammatory drug bornyl acetate (BA) from gastric degradation, ensuring its delivery to the colon. SF effectively shields the microspheres during passage through the small intestine and then facilitates rapid drug release upon reaching the colon. We evaluated the efficacy of this strategy in murine models of both acute and chronic colitis, demonstrating its significant capacity to attenuate pro-inflammatory cytokine secretion, enhance intestinal barrier restitution, and modulate immune cell responses for effective amelioration of colitis-associated symptoms. Upon oral administration of microspheres, their therapeutic efficacy against both acute and chronic UC is demonstrated to be superior to that of a widely used clinical drug, 5-aminosalicylic acid. Overall, the oral hydrogel microspheres offer a promising approach to enhance the therapeutic outcomes of small molecule drug against UC.
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; INTESTINAL MUCUS ; CHALLENGES
资助项目SciTech Innovation Leading Talent Projects in Zhongshan[2019B090904008] ; SciTech Innovation Leading Talent Projects in Zhongshan[2021B0909050003] ; Program of Shanghai Committee of Science and Technology, China[LJ2021001] ; Shanghai Advanced Research Institute, Chinese Academy of Science[21ZR1475200] ; Shanghai Advanced Research Institute, Chinese Academy of Science[22S21902900]
WOS研究方向Engineering
语种英语
WOS记录号WOS:001261639600001
出版者ELSEVIER SCIENCE SA
源URL[http://119.78.100.183/handle/2S10ELR8/312240]  
专题新药研究国家重点实验室
通讯作者Shen, Lan; Wang, Bing; Huan, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yaoyao,Jiang, Yuting,Song, Yijie,et al. Alginate/silk fibroin/Zn 2+composite microspheres for site-specific delivery for enhanced ulcerative colitis therapy[J]. CHEMICAL ENGINEERING JOURNAL,2024,495:13.
APA Du, Yaoyao.,Jiang, Yuting.,Song, Yijie.,Chen, Jie.,Wu, Yueqian.,...&Huan, Yongzhuo.(2024).Alginate/silk fibroin/Zn 2+composite microspheres for site-specific delivery for enhanced ulcerative colitis therapy.CHEMICAL ENGINEERING JOURNAL,495,13.
MLA Du, Yaoyao,et al."Alginate/silk fibroin/Zn 2+composite microspheres for site-specific delivery for enhanced ulcerative colitis therapy".CHEMICAL ENGINEERING JOURNAL 495(2024):13.

入库方式： OAI收割

来源：上海药物研究所

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