中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis

文献类型：期刊论文

作者Cui, Yuan-Yuan4,5,6; Jin, Yang4,5; Sun, Ruo-Nan4,5; Wang, Xue4; Gao, Cheng-Long4; Cui, Xiao-Yun4; Chen, Kai-Xian5; Sun, Yi-Li4,5; Guo, Yue-Wei1,4; Li, Jia2,3,4,5,6
刊名JOURNAL OF MEDICINAL CHEMISTRY
出版日期2024-07-03
卷号67期号:14页码:12248-12260
ISSN号0022-2623
DOI10.1021/acs.jmedchem.4c00950
通讯作者Sun, Yi-Li(yilisun@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要Cembranolides are characteristic metabolites in marine soft corals, with complex structures and widespread biological activities. However, seldom has an intensive pharmacological study been done for these intriguing marine natural products. In this work, systematic chemical investigation was performed on Sinularia pedunculata by HSQC-based small molecule accurate recognition technology (SMART), resulting in the isolation and identification of 31 cembrane-type diterpenoids, including six new ones. In the bioassay, several compounds showed significant anti-inflammatory activities on the inhibition of NO production. The structure-activity relationship (SAR) was comprehensively analyzed, and two most bioactive and less toxic compounds 8 and 9 could inhibit inflammation through suppressing NF-kappa B and MAPK signaling pathways, and reduce the secretion of inflammatory cytokines. In a mouse model of dextran sodium sulfate (DSS)-induced acute colitis, 8 and 9 exhibited good anti-inflammatory effects and the ability to repair the colon epithelium, giving insight into the application of cembranolides as potential ulcerative colitis (UC) agents.
WOS关键词KAPPA-B ; SIGNALING PATHWAY
资助项目National Key Research and Development Program of China[2021YFF0502400] ; National Key Research and Development Program of China[2022YFC2804100] ; National Natural Science Foundation of China[42076099] ; National Natural Science Foundation of China[81903682] ; National Natural Science Foundation of China[82022069] ; Shandong Laboratory Program[SYS202205] ; Taishan Scholars Program[tstp0648] ; Taishan Scholars Program[tsqn202312302] ; Shanghai Science and Technology Committee[19YF1410200] ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ057] ; CAS Youth Interdisciplinary Team
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001265058500001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/312255]  
专题中国科学院上海药物研究所
通讯作者Sun, Yi-Li; Guo, Yue-Wei; Li, Jia; Li, Xu-Wen
作者单位1.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
6.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Yuan-Yuan,Jin, Yang,Sun, Ruo-Nan,et al. The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2024,67(14):12248-12260.
APA Cui, Yuan-Yuan.,Jin, Yang.,Sun, Ruo-Nan.,Wang, Xue.,Gao, Cheng-Long.,...&Li, Xu-Wen.(2024).The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis.JOURNAL OF MEDICINAL CHEMISTRY,67(14),12248-12260.
MLA Cui, Yuan-Yuan,et al."The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis".JOURNAL OF MEDICINAL CHEMISTRY 67.14(2024):12248-12260.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。