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Design and Synthesis of Marine Polybrominated Diphenyl Ether Derivatives as Potential Anti-Inflammatory Agents

文献类型：期刊论文

作者Gao, Ning1,2,3; Gao, Cheng-Long1,2; Chen, Sha1; Wang, Meng-Xue1; Li, Xu-Wen1,2,3
刊名CHEMISTRY & BIODIVERSITY
出版日期2024-07-12
页码6
关键词Polybrominated diphenyl ethers Marine natural products Anti-inflammatory activity
ISSN号1612-1872
DOI10.1002/cbdv.202401179
通讯作者Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要Natural polybrominated diphenyl ethers are generally isolated from sponges and possess a broad range of biological activities. Through screening of our marine natural product library, we discovered that polybrominated diphenyl ethers 5 and 6 exhibit considerable anti-inflammatory activity. In order to expand our repertoire of derivatives for further biological activity studies, we designed and synthesized a series of 5-related polybrominated diphenyl ethers. Importantly, compound 5a showed comparable anti-inflammatory activity while much lower cytotoxicity on lipopolysaccharide (LPS)-induced RAW264.7 cells. Additionally, western blotting analysis showed that 5a reduced the expression of phosphorylated extracellular signal-regulated kinase (p-ERK). Besides, molecular docking experiments were conducted to predict and elucidate the potential mechanisms underlying the varying anti-inflammatory activities exhibited by compounds 5a, 5, and 6. image
资助项目National Key Research and Development Program of China[2021YFF0502400] ; National Natural Science Foundation of China[42076099] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[82304373] ; Shandong Laboratory Program[SYS202205] ; Taishan Scholars Program[tsqn202312302] ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ057] ; China Postdoctoral Science Foundation[2023 M743656] ; Shanghai Super Postdoc Incentive Program[2022683] ; CAS Youth Interdisciplinary Team
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001266403200001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/312276]  
专题中国科学院上海药物研究所
通讯作者Li, Xu-Wen
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Ning,Gao, Cheng-Long,Chen, Sha,et al. Design and Synthesis of Marine Polybrominated Diphenyl Ether Derivatives as Potential Anti-Inflammatory Agents[J]. CHEMISTRY & BIODIVERSITY,2024:6.
APA Gao, Ning,Gao, Cheng-Long,Chen, Sha,Wang, Meng-Xue,&Li, Xu-Wen.(2024).Design and Synthesis of Marine Polybrominated Diphenyl Ether Derivatives as Potential Anti-Inflammatory Agents.CHEMISTRY & BIODIVERSITY,6.
MLA Gao, Ning,et al."Design and Synthesis of Marine Polybrominated Diphenyl Ether Derivatives as Potential Anti-Inflammatory Agents".CHEMISTRY & BIODIVERSITY (2024):6.

入库方式： OAI收割

来源：上海药物研究所

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