Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
文献类型：期刊论文
| 作者 | Xu, Zhuo1,2; Zhang, Naixia1,2 ; Shi, Li2
|
| 刊名 | AMERICAN JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2024 |
| 卷号 | 14期号:6页码:2666-2694 |
| 关键词 | Deubiquitinase UCH family cancer inhibitors |
| ISSN号 | 2156-6976 |
| DOI | 10.62347/OEGE2648 |
| 通讯作者 | Zhang, Naixia(nxzhang@simm.ac.cn) ; Shi, Li(shili@simm.ac.cn) |
| 英文摘要 | Deubiquitinating enzymes (DUBs) are a large group of proteases that reverse ubiquitination process and maintain protein homeostasis. The DUBs have been classified into seven subfamilies according to their primary sequence and structural similarity. As a small subfamily of DUBs, the ubiquitin C -terminal hydrolases (UCHs) subfamily only contains four members including UCHL1, UCHL3, UCHL5, and BRCA1-associated protein -1 (BAP1). Despite sharing the deubiquitinase activity with a similar catalysis mechanism, the UCHs exhibit distinctive biological functions which are mainly determined by their specific subcellular localization and partner substrates. Besides, growing evidence indicates that the UCH enzymes are involved in human malignancies. In this review, the structural information and biological functions of the UCHs are briefly described. Meanwhile, the roles of these enzymes in tumorigenesis and the discovered inhibitors against them are also summarized to give an insight into the cancer therapy with the potential alternative strategy. |
| WOS关键词 | C-TERMINAL HYDROLASE-L1 ; 1ST-IN-CLASS USP1 INHIBITOR ; UBIQUITIN HYDROLASE ; PARKINSONS-DISEASE ; HEPATOCELLULAR-CARCINOMA ; SUBSTRATE-SPECIFICITY ; TUMOR-SUPPRESSOR ; HISTONE H2A ; BRCA1-ASSOCIATED PROTEIN-1 ; CANCER METASTASIS |
| 资助项目 | National Natural Science Foundation of China[32000890] ; National Natural Science Foundation of China[32171220] ; National Natural Science Foundation of China[22107111] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:001260164900001 |
| 出版者 | E-CENTURY PUBLISHING CORP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312282]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Naixia; Shi, Li |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Res Ctr Organ & Biol Mol, State Key Lab Chem Biol, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Zhuo,Zhang, Naixia,Shi, Li. Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2024,14(6):2666-2694. |
| APA | Xu, Zhuo,Zhang, Naixia,&Shi, Li.(2024).Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them.AMERICAN JOURNAL OF CANCER RESEARCH,14(6),2666-2694. |
| MLA | Xu, Zhuo,et al."Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them".AMERICAN JOURNAL OF CANCER RESEARCH 14.6(2024):2666-2694. |
入库方式： OAI收割
来源：上海药物研究所
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