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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A - O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable ' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase

文献类型：期刊论文

作者Zhou, Peng -Jun4,5; Zhao, Ze-Yu4,5; Zhu, Jin-Xin5; Zang, Yi3; Benjamin, Menny M.2; Xiong, Juan1,4; Li, Jia3; Hu, Jin-Feng2,4,5
刊名PHYTOCHEMISTRY
出版日期2024-10-01
卷号226页码:13
关键词Tsuga forrestii Pinaceae Rare and endangered plants (REPs) Diterpenoid acids ATP citrate lyase (ACL) Molecular docking Chemotaxonomy
ISSN号0031-9422
DOI10.1016/j.phytochem.2024.114221
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要An extensive phytochemical investigation on the EtOAc-soluble fraction of the 90% MeOH extract from the twigs and needles of the 'vulnerable' Chinese endemic conifer Tsuga forrestii (Forrest's hemlock) led to the isolation and characterization of 50 structurally diverse diterpenoids, including 15 unreported C-18 carboxylated ones (tsugaforrestiacids A-O, 1-15, resp.). Among them, compounds 1-7 are abieten-18-oic acids, compound 8 is an abieten-18-succinate, and compounds 10-12 are podocarpen-18-oic acids, whereas compounds 13-15 are pimarane-type, isopimarane-type, and totarane-type diterpenoid acids, respectively. Their structures and absolute configurations were determined by a combination of spectroscopic methods, GIAO NMR calculations and DP4+ probability analyses, electronic circular dichroism (ECD) data, and single crystal X-ray diffraction analyses. All the isolates were evaluated for their inhibitory activities against the ATP-citrate lyase (ACL), a key enzyme in cellular metabolism. Tsugaforrestiacids E (5) and H (8) were found to have significant inhibitory effects against ACL, with IC50 values of 5.3 and 6.2 mu M, respectively. The interactions of the bioactive molecules with the ACL enzyme were examined by molecular docking studies. The isolated diterpenoids also provide chemotaxonomic evidence to support the delimitation of Tsuga from its closest sister group (Nothotsuga). The above findings highlight the importance of protecting plant species with unique and diverse secondary metabolites, which may be potential sources of new therapeutic agents for the treating ACL-associated diseases.
WOS关键词ABIETANE DITERPENOIDS ; NATURAL-PRODUCTS ; CONSTITUENTS ; ACID ; HEARTWOOD ; PINACEAE ; LIGNANS ; LEAVES ; TRUNK ; CONES
资助项目National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001271250500001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/312374]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Fudan Univ, Shanghai 201203, Peoples R China
2.Med Univ South Carolina, Coll Pharm & Med, Charleston, SC 29425 USA
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
5.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Peng -Jun,Zhao, Ze-Yu,Zhu, Jin-Xin,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A - O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable ' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase[J]. PHYTOCHEMISTRY,2024,226:13.
APA Zhou, Peng -Jun.,Zhao, Ze-Yu.,Zhu, Jin-Xin.,Zang, Yi.,Benjamin, Menny M..,...&Hu, Jin-Feng.(2024).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A - O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable ' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase.PHYTOCHEMISTRY,226,13.
MLA Zhou, Peng -Jun,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A - O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable ' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase".PHYTOCHEMISTRY 226(2024):13.

入库方式： OAI收割

来源：上海药物研究所

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