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Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity

文献类型：期刊论文

作者Wu, Yuan-Hao12,13; Wang, Guan-Jun12,13; Guo, Chen12,13; Wang, Pei-Pei8,10; Wang, Jun-Yi1; Hu, Xi-Le12,13; Zang, Yi6,7,9; James, Tony D.2,3; Li, Jia4,5,6,7,8,10; He, Xiao-Peng11,12,13
刊名CHEMICAL COMMUNICATIONS
出版日期2024-08-01
卷号60期号:63页码:8240-8243
ISSN号1359-7345
DOI10.1039/d4cc02845g
通讯作者Hu, Xi-Le(xlhu@ecust.edu.cn) ; Zang, Yi(yzang@lglab.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要O-GlcNAcase (OGA) is implicated in several important biological and disease-relevant processes. Here, we synthesized fluorogenic probes for OGA by grafting GlcNAc directly or using a self-immolative linker to the hydroxyl position of 4-hydroxylisoindoline (BHID), a typical excited-state intramolecular proton transfer (ESIPT) probe. The probe was used for a fluorogenic assay to determine the half maximal inhibitory concentration of a known OGA inhibitor and differentiate between OGA and hexosaminidase when GlcNAc is replaced by GlcNPr, where a propionyl group is used instead of an acetyl group. An isoindoline-based fluorogenic probe bearing a self-immolative linker was developed for the sensitive and selective detection of O-GlcNAcase.
资助项目Natural National Science Foundation of China (NSFC)[92253306] ; Natural National Science Foundation of China (NSFC)[82130099] ; Natural National Science Foundation of China (NSFC)[22108077] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Program of Shanghai Science and Technology[23490711600] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering ; State Key Laboratory of Drug Research[SKLDR-2023-KF-10] ; Ministry of Education Key Laboratory on Signalling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University)[2023-MEKLLC-MS/ZD-00*] ; University of Bath ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001270905200001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/312413]  
专题新药研究国家重点实验室
通讯作者Hu, Xi-Le; Zang, Yi; James, Tony D.; Li, Jia; He, Xiao-Peng
作者单位1.Shanghai Starriver Bilingual Sch, 2588 Jindu Rd, Shanghai 201108, Peoples R China
2.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
3.Univ Bath, Dept Chem, Bath BA2 7AY, England
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Beijing 528400, Guangdong, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
7.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
8.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
9.Lingang Lab, Shanghai 201203, Peoples R China
10.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yuan-Hao,Wang, Guan-Jun,Guo, Chen,et al. Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity[J]. CHEMICAL COMMUNICATIONS,2024,60(63):8240-8243.
APA Wu, Yuan-Hao.,Wang, Guan-Jun.,Guo, Chen.,Wang, Pei-Pei.,Wang, Jun-Yi.,...&He, Xiao-Peng.(2024).Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity.CHEMICAL COMMUNICATIONS,60(63),8240-8243.
MLA Wu, Yuan-Hao,et al."Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity".CHEMICAL COMMUNICATIONS 60.63(2024):8240-8243.

入库方式： OAI收割

来源：上海药物研究所

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