Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities
文献类型：期刊论文
| 作者 | Ding, Ao-Xue3,4; Shan, Yi -Ming3,4; Li, Chen-Yue1,4; Qin, Guo -Qing3,4; Chen, Tong2,4; Wang, Qing2,4; Hu, Xiang-Gang2,4; Guo, Peng-Ju1,4; Yu, Hai-Jun3,4 ; Wang, Wen-Qiong4
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 226页码:12 |
| 关键词 | Tithonia diversifolia Asteraceae Sesquiterpene lactones Ferroptosis Cytotoxic effects |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114219 |
| 通讯作者 | Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Eight previously undescribed sesquiterpene lactones ( 1 - 8 ), together with six known ones ( 9 - 14 ) were isolated from the aerial parts of Tithonia diversifolia (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones 2 - 4 share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds 1 and 8 showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers. |
| WOS关键词 | TAGITININ C ; CANCER |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[82373746] ; Shanghai Municipal Science and Technology Major Project[TM202301L001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001271717000001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312419]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-Qiong; Xuan, Li-Jiang |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Ao-Xue,Shan, Yi -Ming,Li, Chen-Yue,et al. Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities[J]. PHYTOCHEMISTRY,2024,226:12. |
| APA | Ding, Ao-Xue.,Shan, Yi -Ming.,Li, Chen-Yue.,Qin, Guo -Qing.,Chen, Tong.,...&Xuan, Li-Jiang.(2024).Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities.PHYTOCHEMISTRY,226,12. |
| MLA | Ding, Ao-Xue,et al."Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities".PHYTOCHEMISTRY 226(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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