Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode
文献类型：期刊论文
| 作者 | Li, Huamei; Dai, Fuda; Liu, Hanyu; Tao, Qi ; Hu, Jie; Zhang, Yangrong; Xiao, Zhenping; Rupenthal, Ilva D. D.; Li, Huihui; Yang, Fan
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| 刊名 | DRUG DELIVERY
 |
| 出版日期 | 2023 |
| 卷号 | 30期号:1页码:2184312 |
| 关键词 | SOLID LIPID NANOPARTICLES IN-VITRO RELEASE MONTMORILLONITE GLAUCOMA EYE SYSTEM FORMULATION CHITOSAN SURFACE RETENTION |
| ISSN号 | 1071-7544 |
| DOI | 10.1080/10717544.2023.2184312 |
| 英文摘要 | Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the anti-glaucoma drug betaxolol hydrochloride (BHC) exhibited sustained drug release and thus intraocular pressure (IOP) lowering effects. Here, we investigated the effect of physicochemical particle parameters on the micro-interactions with tear film mucins and corneal epithelial cells. Results showed that the MT-BHC SLNs and MT-BHC MPs eye drops significantly prolonged the precorneal retention time due to their higher viscosity and lower surface tension and contact angle compared with the BHC solution, with MT-BHC MPs exhibiting the longest retention due to their stronger hydrophobic surface. The cumulative release of MT-BHC SLNs and MT-BHC MPs was up to 87.78% and 80.43% after 12 h, respectively. Tear elimination pharmacokinetics study further confirmed that the prolonged precorneal retention time of the formulations was due to the micro-interaction between the positively charged formulations and the negatively charged tear film mucins. Moreover, the area under the IOP reduction curve (AUC) of MT-BHC SLNs and MT-BHC MPs was 1.4 and 2.5 times that of the BHC solution. Accordingly, the MT-BHC MPs also exhibit the most consistent and long-lasting IOP-lowering effect. Ocular irritation experiments showed no significant toxicity of either. Taken together, MT MPs may have the potential for more effective glaucoma treatment. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000943033600001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/80357]  |
| 专题 | 中国科学院矿物学与成矿学重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Huamei,Dai, Fuda,Liu, Hanyu,et al. Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode[J]. DRUG DELIVERY,2023,30(1):2184312. |
| APA | Li, Huamei.,Dai, Fuda.,Liu, Hanyu.,Tao, Qi.,Hu, Jie.,...&Hou, Dongzhi.(2023).Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode.DRUG DELIVERY,30(1),2184312. |
| MLA | Li, Huamei,et al."Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode".DRUG DELIVERY 30.1(2023):2184312. |
入库方式： OAI收割
来源：广州地球化学研究所
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