The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance
文献类型：期刊论文
| 作者 | Arunachalam, Karuppusamy; Sreeja, Puthanpura Sasidharan; Yang, Xuefei
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| 刊名 | FRONTIERS IN PHARMACOLOGY
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| 出版日期 | 2022 |
| 卷号 | 13页码:874474 |
| 关键词 | reactive oxygen species oxidative stress antioxidant diabetes mellitus mushroom polysaccharides AGARICUS-BLAZEI MURILL GANODERMA-LUCIDUM POLYSACCHARIDES ACTIVATED SIGNALING PATHWAYS TYPE-2 DIABETES-MELLITUS PROTEIN-KINASE-C MT-ALPHA-GLUCAN MEDICINAL MUSHROOM SUBMERGED-CULTURE PHELLINUS-LINTEUS STRUCTURAL-CHARACTERIZATION |
| DOI | 10.3389/fphar.2022.874474 |
| 英文摘要 | Diabetes mellitus is a prevalent metabolic and endocrine illness affecting people all over the world and is of serious health and financial concern. Antidiabetic medicine delivered through pharmacotherapy, including synthetic antidiabetic drugs, are known to have several negative effects. Fortunately, several natural polysaccharides have antidiabetic properties, and the use of these polysaccharides as adjuncts to conventional therapy is becoming more common, particularly in underdeveloped nations. Oxidative stress has a critical role in the development of diabetes mellitus (DM). The review of current literature presented here focusses, therefore, on the antioxidant properties of mushroom polysaccharides used in the management of diabetic complications, and discusses whether these antioxidant properties contribute to the deactivation of the oxidative stress-related signalling pathways, and to the amelioration of beta-cell dysfunction and insulin resistance. In this study, we conducted a systematic review of the relevant information concerning the antioxidant and antidiabetic effects of mushrooms from electronic databases, such as PubMed, Scopus or Google Scholar, for the period 1994 to 2021. In total, 104 different polysaccharides from mushrooms have been found to have antidiabetic effects. Most of the literature on mushroom polysaccharides has demonstrated the beneficial effects of these polysaccharides on reactive oxygen and nitrogen species (RONS) levels. This review discuss the effects of these polysaccharides on hyperglycemia and other alternative antioxidant therapies for diabetic complications through their applications and limits, in order to gain a better understanding of how they can be used to treat DM. Preclinical and phytochemical investigations have found that most of the active polysaccharides extracted from mushrooms have antioxidant activity, reducing oxidative stress and preventing the development of DM. Further research is necessary to confirm whether mushroom polysaccharides can effectively alleviate hyperglycemia, and the mechanisms by which they do this, and to investigate whether these polysaccharides might be utilized as a complementary therapy for the prevention and management of DM in the future. |
| WOS记录号 | WOS:000797932500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75642]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Arunachalam, Karuppusamy,Sreeja, Puthanpura Sasidharan,Yang, Xuefei. The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance[J]. FRONTIERS IN PHARMACOLOGY,2022,13:874474. |
| APA | Arunachalam, Karuppusamy,Sreeja, Puthanpura Sasidharan,&Yang, Xuefei.(2022).The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance.FRONTIERS IN PHARMACOLOGY,13,874474. |
| MLA | Arunachalam, Karuppusamy,et al."The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance".FRONTIERS IN PHARMACOLOGY 13(2022):874474. |
入库方式： OAI收割
来源：昆明植物研究所
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