Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels
文献类型：期刊论文
| 作者 | Su, Deyuan; Gong, Ye; Li, Songyu; Yang, Jian; Nian, Yin
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| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2022 |
| 卷号 | 13页码:1081697 |
| 关键词 | Cyclovirobuxine D Ca(v)3 2 Ca(v)2 Buxus microphylla analgesic effects ROOT GANGLION NEURONS CALCIUM-CHANNELS CELL-PROLIFERATION PACLITAXEL RAT RECEPTOR GENE EXPRESSION APOPTOSIS CURRENTS |
| DOI | 10.3389/fphar.2022.1081697 |
| 英文摘要 | Cyclovirobuxine D (CVB-D), the main active constituent of traditional Chinese medicine Buxus microphylla, was developed as a safe and effective cardiovascular drug in China. B. microphylla has also been used to relieve various pain symptoms for centuries. In this study, we examined and uncovered strong and persistent analgesic effects of cyclovirobuxine D against several mouse models of pain, including carrageenan- and CFA-induced inflammatory pain and paclitaxel-mediated neuropathic hypersensitivity. Cyclovirobuxine D shows comparable analgesic effects by intraplantar or intraperitoneal administration. Cyclovirobuxine D potently inhibits voltage-gated Ca(v)2.2 and Ca(v)3.2 channels but has negligible effects on a diverse group of nociceptive ion channels distributed in primary afferent neurons, including Na(v)1.7, Na(v)1.8, TRPV1, TPRA1, TRPM8, ASIC3, P2X2 and P2X4. Moreover, inhibition of Ca(v)3.2, rather than Ca(v)2.2, plays a dominant role in attenuating the excitability of isolated dorsal root ganglion neurons and pain relieving effects of cyclovirobuxine D. Our work reveals that a currently in-use cardiovascular drug has strong analgesic effects mainly via blockade of Ca(v)3.2 and provides a compelling rationale and foundation for conducting clinical studies to repurpose cyclovirobuxine D in pain management. |
| WOS记录号 | WOS:000907595600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75643]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Su, Deyuan,Gong, Ye,Li, Songyu,et al. Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels[J]. FRONTIERS IN PHARMACOLOGY,2022,13:1081697. |
| APA | Su, Deyuan,Gong, Ye,Li, Songyu,Yang, Jian,&Nian, Yin.(2022).Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels.FRONTIERS IN PHARMACOLOGY,13,1081697. |
| MLA | Su, Deyuan,et al."Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels".FRONTIERS IN PHARMACOLOGY 13(2022):1081697. |
入库方式： OAI收割
来源：昆明植物研究所
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