Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors
文献类型：期刊论文
| 作者 | Wang, Chen ; Zhu, Ming-Hao; Sun, Na; Shen, Wei; Jiang, Ning; Zhao, Qin-Shi; Zhang, Yong-Xiang; Huang, Yan; Zhou, Wen-Xia
|
| 刊名 | FRONTIERS IN NEUROSCIENCE
 |
| 出版日期 | 2022 |
| 卷号 | 16页码:1071068 |
| 关键词 | isorhynchophylline (PubChem CID 3037048) corticosterone long-term potentiation chronic unpredictable mild stress D-serine NMDA receptors CHRONIC MILD STRESS DEPRESSION-LIKE BEHAVIORS SYNAPTIC PLASTICITY HIPPOCAMPAL PLASTICITY DENTATE GYRUS CORTICOSTERONE MEMORY BRAIN RHYNCHOPHYLLINE IMPROVES |
| DOI | 10.3389/fnins.2022.1071068 |
| 英文摘要 | IntroductionIsorhynchophylline is one of the main active ingredients from Uncaria rhynchophylla, the effects and mechanisms of isorhynchophylline on stress-induced emotional disorders and cognitive impairment remain unclear. MethodsLong-term potentiation (LTP) in vivo was used for synaptic plasticity evaluation; chronic unpredictable mild stress (CUMS) model was used to evaluate the effect of isorhynchophylline on stress induced emotional disorders and cognitive impairment; sucrose preference test (SPT), open field test (OFT), and elevated plus maze (EPM) were used to evaluate emotional disorders; morris water maze (MWM) test was used to evaluate cognitive impairment; Western blotting (WB) was used to the expression of proteins; high performance liquid chromatography (HPLC) was used to quantify neurotransmitters; Nissl staining was used to identify pathological changes induced by stress. ResultsIn this study, we found that isorhynchophylline improved corticosterone-induced in vivo LTP impairment significantly, indicating positive effects on stress. Therefore, 28-day CUMS model was adopted to evaluate the anti-stress effects of isorhynchophylline. The results showed that isorhynchophylline improved CUMS-induced weight loss, anxiety- and depression-like behaviors, and spatial memory impairment. Isorhynchophylline reduced CUMS-induced corticosterone elevation. N-methyl-D-aspartic acid (NMDA) receptors play an important role in the process of emotion and memory. Glutamate and the expression of GluN2B increased in the CUMS mice, while D-serine and the expression of serine racemase (SR) decreased significantly, and isorhynchophylline restored these changes to normal level. ConclusionThese results indicated that isorhynchophylline ameliorated stress-induced emotional disorders and cognitive impairment, modulating NMDA receptors might be one of the underlying mechanisms. |
| WOS记录号 | WOS:000905494700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75645]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Chen,Zhu, Ming-Hao,Sun, Na,et al. Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors[J]. FRONTIERS IN NEUROSCIENCE,2022,16:1071068. |
| APA | Wang, Chen.,Zhu, Ming-Hao.,Sun, Na.,Shen, Wei.,Jiang, Ning.,...&Zhou, Wen-Xia.(2022).Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors.FRONTIERS IN NEUROSCIENCE,16,1071068. |
| MLA | Wang, Chen,et al."Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors".FRONTIERS IN NEUROSCIENCE 16(2022):1071068. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。