Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3
文献类型：期刊论文
| 作者 | Yu, Chong; Nian, Yin ; Chen, Huanhua; Liang, Shuwen; Sun, Mengyang; Pei, Yuehu; Wang, Haifeng
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| 刊名 | FRONTIERS IN CHEMISTRY
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| 出版日期 | 2022 |
| 卷号 | 10页码:950726 |
| 关键词 | secondary metabolites plant endophytic fungus Phoma sp pyranone derivatives HL-60 inhibition |
| DOI | 10.3389/fchem.2022.950726 |
| 英文摘要 | Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11S, 13R-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9S, 11R-(+)-ascosalitoxin (10) were isolated from the endophytic fungus Phoma sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC50 values of 31.02, 34.62, and 27.90 mu M, respectively. |
| WOS记录号 | WOS:000829663900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75655]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yu, Chong,Nian, Yin,Chen, Huanhua,et al. Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3[J]. FRONTIERS IN CHEMISTRY,2022,10:950726. |
| APA | Yu, Chong.,Nian, Yin.,Chen, Huanhua.,Liang, Shuwen.,Sun, Mengyang.,...&Wang, Haifeng.(2022).Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3.FRONTIERS IN CHEMISTRY,10,950726. |
| MLA | Yu, Chong,et al."Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3".FRONTIERS IN CHEMISTRY 10(2022):950726. |
入库方式： OAI收割
来源：昆明植物研究所
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