Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition
文献类型：期刊论文
| 作者 | Long, Xianwen; Zhang, Min; Yang, Xiaodong; Deng, Jun |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2022 |
| 卷号 | 24期号:6页码:1303-1307 |
| 关键词 | LIGANDS THIOLS |
| DOI | 10.1021/acs.orglett.1c04282 |
| 英文摘要 | A bioinspired strategy is described for the total synthesis of spiroaxillarone A, which exhibited significant antimalarial activity against resistant Plasmodium falciparum (IC50 = 2.32 mu M). The key steps include an intermolecular ethanethiol Michael addition, o-quinone Michael addition, and subsequent beta-ethanethiol elimination. This synthetic sequence provides a potential biosynthetic pathway of spiroaxillarone A. |
| WOS记录号 | WOS:000758180800008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75664]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Long, Xianwen,Zhang, Min,Yang, Xiaodong,et al. Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition[J]. ORGANIC LETTERS,2022,24(6):1303-1307. |
| APA | Long, Xianwen,Zhang, Min,Yang, Xiaodong,&Deng, Jun.(2022).Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition.ORGANIC LETTERS,24(6),1303-1307. |
| MLA | Long, Xianwen,et al."Total Synthesis of (+/-)-Spiroaxillarone A via a Reversible Sulfa- Michael Addition".ORGANIC LETTERS 24.6(2022):1303-1307. |
入库方式： OAI收割
来源：昆明植物研究所
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