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Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways

文献类型：期刊论文

作者An, Pei-Pei2,3; Huang, Hui1,2; Ru, Su-Jie2; Gao, Yuan2; Ren, Yu-Hao2; Gao, Kun3; Zhou, Hu1,2; Zhou, Bin2; Yue, Jian-Min2,3
刊名BIOORGANIC CHEMISTRY
出版日期2024-10-01
卷号151页码:14
关键词Strophanthus divaricatus Steroid glycosides Structural elucidation Structure-activity relationship Anticancer mechanism
ISSN号0045-2068
DOI10.1016/j.bioorg.2024.107619
通讯作者Zhou, Hu(zhouhu@simm.ac.cn) ; Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Two rare 8-hydroxysteroid glycosides (6-7), and their downstream metabolites (1-5) with an unprecedented 6/ 6/5/5/5-pentacyclic scaffold, together with seven known analogues (8-14) were isolated from the twigs and leaves of Strophanthus divaricatus. Their structures were fully assigned by analysis of the spectroscopic and ECD data, NMR calculations, X-ray crystallographic study, and chemical methods. In addition, the inhibitory effects of 1-14 on liver and lung cancer cell lines were evaluated, and preliminary structure-activity relationship was discussed. Data-independent acquisition (DIA)-based quantitative proteomic analysis and biological verification of H1299 cells suggested that this family of compounds may play an anticancer role by suppressing both DNA damage response (DDR) and mTOR/S6K signaling pathways.
WOS关键词D-SARMENTOSE ; L-DIGINOSE ; INHIBITORS
资助项目National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[82293685] ; National Natural Science Foundation of China[22107106] ; Shanghai Municipal Science and Technology Major Project ; Youth Innovation Promotion Association of CAS[2022283]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001273867300001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/312520]  
专题新药研究国家重点实验室
通讯作者Zhou, Hu; Zhou, Bin; Yue, Jian-Min
作者单位1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 An, Pei-Pei,Huang, Hui,Ru, Su-Jie,et al. Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways[J]. BIOORGANIC CHEMISTRY,2024,151:14.
APA An, Pei-Pei.,Huang, Hui.,Ru, Su-Jie.,Gao, Yuan.,Ren, Yu-Hao.,...&Yue, Jian-Min.(2024).Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways.BIOORGANIC CHEMISTRY,151,14.
MLA An, Pei-Pei,et al."Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways".BIOORGANIC CHEMISTRY 151(2024):14.

入库方式： OAI收割

来源：上海药物研究所

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