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Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis

文献类型：期刊论文

作者Gao, Jialu5,6; Yu, Kai6; Luo, Qiusi2,3,6; Deng, Mingbo2,3,6; Hou, Xiaowen2,3,6; Wang, Wumei1,6; Zeng, Xiaodong2,3; Xiong, Xiaoxing6; He, Yong4; Hong, Xuechuan1,5,6
刊名JOURNAL OF MEDICINAL CHEMISTRY
出版日期2024-07-12
卷号67期号:14页码:12428-12438
ISSN号0022-2623
DOI10.1021/acs.jmedchem.4c01208
通讯作者Xiong, Xiaoxing(xiaoxingxiong@whu.edu.cn) ; He, Yong(heyong@whu.edu.cn) ; Hong, Xuechuan(xhy78@whu.edu.cn) ; Xiao, Yuling(xiaoyl@whu.edu.cn)
英文摘要Targeting Ca2+/calmodulin-dependent protein kinase gamma (CaMKII gamma) in macrophages using RNAi nanotechnology represents an innovative and promising strategy in the diagnosis and treatment of atherosclerosis. Nevertheless, it remains elusive because of the current challenges associated with the systemic delivery of siRNA nanoparticle (NP) to atheromatous plaques and the complexity of atherosclerotic plaques. Here, we demonstrate the potential of a thienothiadiazole-based near-infrared-II (NIR-II) organic aggregation-induced emission (AIE) platform encapsulated with the Camk2g siRNA to effectively target CaMKII gamma in macrophages for dynamic imaging and image-guided gene therapy of atherosclerosis. The nanoparticles effectively decreased CaMKII gamma expression and increased the expression of the efferocytosis receptor MerTK in plaque macrophages, leading to a reduction in the necrotic core area of the lesion in an aortic plaque model. Our theranostic approach highlights the substantial promise of near-infrared II (NIR-II) AIEgens for imaging and image-guided therapy of atherosclerosis.
WOS关键词IN-VIVO ; MACROPHAGES ; PLAQUES
资助项目National Key R&D Program of China[2020YFA0908800] ; National Natural Science Foundation of China[82273796] ; National Natural Science Foundation of China[81773674] ; National Natural Science Foundation of China[82372005] ; National Natural Science Foundation of China[82171986] ; Shenzhen Science and Technology Research Grant[JCYJ20220530140605012] ; Shenzhen Science and Technology Research Grant[JCYJ20230807090100002] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University[ZNJC202209] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[XZ202301ZY0014G] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001277961300001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/312529]  
专题新药研究国家重点实验室
通讯作者Xiong, Xiaoxing; He, Yong; Hong, Xuechuan; Xiao, Yuling
作者单位1.Wuhan Univ, CAS, Shenzhen Inst, Key Lab Virol & Biosafety, Shenzhen 518057, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Wuhan Univ, Zhongnan Hosp, Dept Nucl Med, Wuhan 430060, Peoples R China
5.Wuhan Univ, Zhongnan Hosp, Dept Cardiol, Wuhan 430060, Peoples R China
6.Wuhan Univ, Renmin Hosp, Sch Pharmaceut Sci, Dept Neurosurg, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Jialu,Yu, Kai,Luo, Qiusi,et al. Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2024,67(14):12428-12438.
APA Gao, Jialu.,Yu, Kai.,Luo, Qiusi.,Deng, Mingbo.,Hou, Xiaowen.,...&Xiao, Yuling.(2024).Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis.JOURNAL OF MEDICINAL CHEMISTRY,67(14),12428-12438.
MLA Gao, Jialu,et al."Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis".JOURNAL OF MEDICINAL CHEMISTRY 67.14(2024):12428-12438.

入库方式： OAI收割

来源：上海药物研究所

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