Three-Component Allylic Alkylation Reaction of α-Diazo Ketones with Water and Allyl Carbonates for Construction of Homoallylic Alcohols
文献类型：期刊论文
| 作者 | Yin, Liping4; Zhang, Xinyi3; Wang, Baofan1,2; He, Mingjin1; Li, Yi1; Wang, Shaozhen4; Jing, Tongfei1; Kang, Zhenghui1,2,3 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2024-08-05 |
| 页码 | 9 |
| 关键词 | metal carbene multicomponent reactions oxonium ylides cooperative catalysis homoallylic alcohols |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.202400364 |
| 通讯作者 | Li, Yi(liyi@simm.ac.cn) ; Jing, Tongfei(jingtongfei0379@zidd.ac.cn) ; Kang, Zhenghui(kangzhenghui@simm.ac.cn) |
| 英文摘要 | A three-component allylic alkylation reaction of alpha-diazo ketones, water and allyl carbonate under the cooperative catalysis of Rh2(OAc)4, Pd2(dba)3 and Br & oslash;nsted acid was disclosed. This method provides an expeditious access to alpha-keto homoallylic alcohols in good to high yields. Controlled experiments support that the transformations proceed through cross-interception of two active intermediates Pd-allyl species and enol intermediates derived from oxonium ylides. Moreover, synthetic transformations of the generated products enable the creation of motifs enriched with dense functional groups, underscoring their potential as valuable building blocks. image |
| WOS关键词 | ENANTIOSELECTIVE SYNTHESIS ; DUAL CATALYSIS ; CASCADE REACTION ; ACID ; ALDEHYDES ; PYRAZOL-5-ONES ; DERIVATIVES ; IRIDIUM ; YLIDES ; ESTERS |
| 资助项目 | National Natural Science Foundation of China[21901262] ; National Natural Science Foundation of China[92056201] ; Guangdong Basic and Applied Basic Research Foundation, China[2024A1515030037] ; Guangdong Basic and Applied Basic Research Foundation, China[2021A1515010231] ; Guangdong Basic and Applied Basic Research Foundation, China[2023A1515110403] ; China Postdoctoral Science Foundation[2023M743925] ; Program for Excellent Sci-tech Innovation Teams of Universities in Anhui Province[2023AH010073] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001283365400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312568]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yi; Jing, Tongfei; Kang, Zhenghui |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China 3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China 4.Wannan Med Coll, Inst Synth & Applicat Med Mat, AnHui Prov Engn Res Ctr Dent Mat & Applicat, Dept Pharm, Wuhu 241002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Liping,Zhang, Xinyi,Wang, Baofan,et al. Three-Component Allylic Alkylation Reaction of α-Diazo Ketones with Water and Allyl Carbonates for Construction of Homoallylic Alcohols[J]. ADVANCED SYNTHESIS & CATALYSIS,2024:9. |
| APA | Yin, Liping.,Zhang, Xinyi.,Wang, Baofan.,He, Mingjin.,Li, Yi.,...&Kang, Zhenghui.(2024).Three-Component Allylic Alkylation Reaction of α-Diazo Ketones with Water and Allyl Carbonates for Construction of Homoallylic Alcohols.ADVANCED SYNTHESIS & CATALYSIS,9. |
| MLA | Yin, Liping,et al."Three-Component Allylic Alkylation Reaction of α-Diazo Ketones with Water and Allyl Carbonates for Construction of Homoallylic Alcohols".ADVANCED SYNTHESIS & CATALYSIS (2024):9. |
入库方式： OAI收割
来源：上海药物研究所
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