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LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet

文献类型：期刊论文

作者Xie, Xianghong6,7; Gao, Mingyue6,7; Wang, Heping6,7; Zhang, Minglong5,6; Zhao, Wei6,7; Li, Chunmei6,7; Zhang, Weihong4; Yang, Jiahui4; Zhang, Yinliang6,7; Chen, Enhui5,6
刊名FASEB JOURNAL
出版日期2024-08-15
卷号38期号:15页码:15
关键词chromatin remodeling glycogenesis insulin resistance lncRNA-Snhg3
ISSN号0892-6638
DOI10.1096/fj.202401064R
通讯作者Li, Meixia(limeixia@ibp.ac.cn) ; Qiao, Aijun(qiaoaijun@simm.ac.cn) ; Liu, Xiaojun(xiaojunliu@ibms.pumc.edu.cn)
英文摘要Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis. Glucose tolerance improved in hepatocyte-specific Snhg3 knock-in (Snhg3-HKI) mice, while it worsened in hepatocyte-specific Snhg3 knockout (Snhg3-HKO) mice. Furthermore, hepatic glycogenesis had shown remarkable increase in Snhg3-HKI mice and reduction in Snhg3-HKO mice, respectively. Mechanistically, Snhg3 increased mRNA and protein expression levels of PPP1R3B through inducing chromatin remodeling and promoting the phosphorylation of protein kinase B. Collectively, these results suggested that lncRNA-Snhg3 plays a critical role in hepatic glycogenesis.
WOS关键词PROTEIN PHOSPHATASE-1 ; SYNTHASE KINASE-3 ; INSULIN ; METABOLISM ; GLUCOSE ; LIVER ; PTG
资助项目Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[CIFMS2021-I2M-1-016] ; National Key R&D Program of China[2022YFC2504002] ; National Key R&D Program of China[2022YFC2504003] ; Beijing Natural Science Foundation[7242094] ; National Natural Science Foundation of China[82270925] ; High-level New R&D Institute of Department of Science and Technology of Guangdong Province[2019B090904008] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
WOS记录号WOS:001289146300001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/312694]  
专题中国科学院上海药物研究所
通讯作者Li, Meixia; Qiao, Aijun; Liu, Xiaojun
作者单位1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, 15 Datun Rd, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
4.Shanxi Med Univ, Dept Microbiol & Immunol, Taiyuan, Peoples R China
5.Chinese Acad Med Sci, Dept Physiol, Inst Basic Med Sci, Beijing 100730, Peoples R China
6.Peking Union Med Coll, Sch Basic Med, 5 Dongdan Santiao, Beijing 100005, Peoples R China
7.Chinese Acad Med Sci, Dept Biochem & Mol Biol, State Key Lab Common Mech Res Major Dis, Inst Basic Med Sci, 5 Dongdan Santiao, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Xianghong,Gao, Mingyue,Wang, Heping,et al. LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet[J]. FASEB JOURNAL,2024,38(15):15.
APA Xie, Xianghong.,Gao, Mingyue.,Wang, Heping.,Zhang, Minglong.,Zhao, Wei.,...&Liu, Xiaojun.(2024).LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet.FASEB JOURNAL,38(15),15.
MLA Xie, Xianghong,et al."LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet".FASEB JOURNAL 38.15(2024):15.

入库方式： OAI收割

来源：上海药物研究所

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