An insoluble cellulose nanofiber with robust expansion capacity protects against obesity
文献类型：期刊论文
| 作者 | Yu, Jian6,7; Gao, Mingyuan6; Wang, Li6; Guo, Xiaozhen5,6; Liu, Xiaodi6; Sheng, Maozheng6; Cheng, Shimiao6; Guo, Yingying6; Wang, Jiawen6; Zhao, Cheng6 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 277页码:14 |
| 关键词 | Obesity Citric acid-crosslinked carboxymethyl cellulose nanofiber Food intake Probiotics Conjugated bile acids Energy expenditure |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.134401 |
| 通讯作者 | Ma, Xinran(xrma@bio.ecnu.edu.cn) ; Xie, Cen(xiecen@simm.ac.cn) ; Zhang, Qiang(qzhang@bio.ecnu.edu.cn) ; Xu, Lingyan(lyxu@bio.ecnu.edu.cn) |
| 英文摘要 | An imbalance between energy intake and energy expenditure predisposes obesity and its related metabolic diseases. Soluble dietary fiber has been shown to improve metabolic homeostasis mainly via microbiota reshaping. However, the application and metabolic effects of insoluble fiber are less understood. Herein, we employed nanotechnology to design citric acid-crosslinked carboxymethyl cellulose nanofibers (CL-CNF) with a robust capacity of expansion upon swelling. Supplementation with CL-CNF reduced food intake and delayed digestion rate in mice by occupying stomach. Besides, CL-CNF treatment mitigated diet-induced obesity and insulin resistance in mice with enhanced energy expenditure, as well as ameliorated inflammation in adipose tissue, intestine and liver and reduced hepatic steatosis, without any discernible signs of toxicity. Additionally, CL-CNF supplementation resulted in enrichment of probiotics such as Bifidobacterium and decreased in the relative abundances of deleterious microbiota expressing bile salt hydrolase, which led to increased levels of conjugated bile acids and inhibited intestinal FXR signaling to stimulate the release of GLP-1. Taken together, our findings demonstrate that CL-CNF administration protects mice from diet-induced obesity and metabolic dysfunction by reducing food intake, enhancing energy expenditure and remodeling gut microbiota, making it a potential therapeutic strategy against metabolic diseases. |
| WOS关键词 | GLUCAGON-LIKE PEPTIDE-1 ; DIET-INDUCED OBESITY ; CHAIN FATTY-ACIDS ; GUT MICROBIOTA ; METABOLIC SYNDROME ; ADIPOSE-TISSUE ; FOOD-INTAKE ; BILE-ACIDS ; GHRELIN ; FIBER |
| 资助项目 | National Key Research and Development Program of China[2019YFA09004500] ; National Key Research and Development Program of China[2023YFA1800400] ; Fundamental Research Funds for the Central Universities[40500-20101-222383] ; National Natural Science Foundation of China[82300979] ; National Natural Science Foundation of China[32325024] ; National Natural Science Foundation of China[32222024] ; National Natural Science Foundation of China[32271224] ; National Natural Science Foundation of China[32071148] ; Science and Technology Commission of Shanghai Municipality[22ZR1421200] ; Science and Technology Commission of Shanghai Municipality[21140904300] ; Shuguang Program of Shanghai Education Development Foundation ; Shanghai Municipal Education Commission[23SG22] ; Natural Science Foundation of Chongqing, China[CSTB2022NSCQ-JQX0033] ; China Postdoctoral Science Foundation[2023M741184] ; ECNU public platform for Innovation[011] ; Instruments sharing platform of School of Life Sciences |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001288993800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312697]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ma, Xinran; Xie, Cen; Zhang, Qiang; Xu, Lingyan |
| 作者单位 | 1.East China Normal Univ, Chongqing Key Lab Precis Opt, Chongqing Inst, Chongqing, Peoples R China 2.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 3.East China Normal Univ, Shanghai Frontiers Sci Ctr Genome Editing & Cell T, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Shanghai Key Lab Diabet Mellitus,Shanghai Clin Ctr, Shanghai 200233, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Sch Life Sci, Shanghai 200241, Peoples R China 7.Southern Med Univ, Dept Endocrinol & Metab, Fengxian Cent Hosp, Shanghai 201499, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jian,Gao, Mingyuan,Wang, Li,et al. An insoluble cellulose nanofiber with robust expansion capacity protects against obesity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,277:14. |
| APA | Yu, Jian.,Gao, Mingyuan.,Wang, Li.,Guo, Xiaozhen.,Liu, Xiaodi.,...&Xu, Lingyan.(2024).An insoluble cellulose nanofiber with robust expansion capacity protects against obesity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,277,14. |
| MLA | Yu, Jian,et al."An insoluble cellulose nanofiber with robust expansion capacity protects against obesity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 277(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。