VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy
文献类型：期刊论文
| 作者 | Liu, Han5; Su, Peihong5; Li, Yuanyuan5; Hoover, Alex5; Hu, Sophie5; King, Sarah A.5; Zhao, Jing5; Guan, Jun-lin4; Chen, Shao-Yu3; Zhao, Yingming5 |
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2024-08-05 |
| 卷号 | 59期号:15页码:17 |
| ISSN号 | 1534-5807 |
| DOI | 10.1016/j.devcel.2024.05.004 |
| 通讯作者 | Wu, Xiaoyang(xiaoyangwu@uchicago.edu) |
| 英文摘要 | Differentiation of murine epidermal stem/progenitor cells involves the permanent withdrawal from the cell cycle, the synthesis of various protein and lipid components for the cornified envelope, and the controlled dissolution of cellular organelles and nuclei. Deregulated epidermal differentiation contributes to the development of various skin diseases, including skin cancers. With a genome-wide shRNA screen, we identified vesicle-associated membrane protein 2 ( VAMP2 ) as a critical factor involved in skin differentiation. Deletion of VAMP2 leads to aberrant skin stratification and enucleation in vivo. . With quantitative proteomics, we further identified an autophagy protein, focal adhesion kinase family interacting protein of 200 kDa (FIP200), as a binding partner of VAMP2. Additionally, we showed that both VAMP2 and FIP200 are critical for murine keratinocyte enucleation and epidermal differentiation. Loss of VAMP2 or FIP200 enhances cutaneous carcinogenesis in vivo. . Together, our findings identify important molecular mechanisms underlying epidermal differentiation and skin tumorigenesis. |
| WOS关键词 | AUTOPHAGY DEGRADES ; STEM-CELLS ; FIP200 ; DEGRADATION ; COMPLEX ; PROTEIN ; SNARES ; KERATINOCYTES ; TUMORIGENESIS ; ENVELOPE |
| 资助项目 | NIH[R01 AR078555] ; NIH[R01 DA047785] ; NIH[R21 AR080761] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001289657300001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312709]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wu, Xiaoyang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Chem Prote Ctr, Shanghai, Peoples R China 3.Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA 4.Univ Cincinnati, Coll Med, Dept Canc Biol, Cincinnati, OH 45267 USA 5.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA |
| 推荐引用方式 GB/T 7714 | Liu, Han,Su, Peihong,Li, Yuanyuan,et al. VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy[J]. DEVELOPMENTAL CELL,2024,59(15):17. |
| APA | Liu, Han.,Su, Peihong.,Li, Yuanyuan.,Hoover, Alex.,Hu, Sophie.,...&Wu, Xiaoyang.(2024).VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy.DEVELOPMENTAL CELL,59(15),17. |
| MLA | Liu, Han,et al."VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy".DEVELOPMENTAL CELL 59.15(2024):17. |
入库方式： OAI收割
来源：上海药物研究所
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