Pentacyclic triterpenoids as potential ACL inhibitors from the rare medicinal plant Semiliquidambar cathayensis
文献类型：期刊论文
| 作者 | Wu, Yu-Fei4; Zhao, Ze-Yu3,4; Yang, Min-Jie2; He, Yu-Hang4; Zang, Yi1 ; Li, Jia1; Hu, Jin-Feng3; Xiong, Juan4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-07-01 |
| 卷号 | 176页码:10 |
| 关键词 | Semiliquidambar cathayensis Triterpenoids Semiliquidacids ACL (ATP-citrate lyase) inhibitor Molecular docking |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.106018 |
| 通讯作者 | Hu, Jin-Feng(jfhu@tzc.edu.cn) ; Xiong, Juan(jxiong@fudan.edu.cn) |
| 英文摘要 | An extensive phytochemical investigation on the rare medicinal plant Semiliquidambar cathayensis (family: Hamamelidaceae) led to the isolation of four new (1-4, 1 - 4 , named semiliquidacids A-D, respectively) and 25 related known pentacyclic triterpenoids. The new structures with absolute configurations were elucidated by spectroscopic methods, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. Compound 1 represents the first naturally occurring ursane-type triterpenoid featuring an uncommon C-25 formyl group. Compound 4 and oleanolic acid (13) 13 ) exhibited remarkable inhibitory effects against the ATP- citrate lyase (ACL, an emerging drug target for hyperlipidemia and related metabolic disorders) with IC50 50 values of 6.5 and 11.9 mu M, respectively. The molecular interaction and binding mode between the bioactive triterpenoids and ACL were elaborated by conducting a molecular docking study. Meanwhile, the chemotaxonomic significance of the isolated triterpenoids has been briefly discussed. |
| WOS关键词 | ATP-CITRATE-LYASE ; BEMPEDOIC ACID ; CONSTITUENTS ; SAPONINS ; LUPANE ; PART ; ROOT |
| 资助项目 | National Natural Science Foundation of China (NSFC)[82373752] ; National Natural Science Foundation of China (NSFC)[21937002] ; Science and Technology Commission of Shanghai Municipality[22ZR1414400] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001294502600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312815]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hu, Jin-Feng; Xiong, Juan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Fudan Univ, Huashan Hosp, Dept Emergency Med, Shanghai 200040, Peoples R China 3.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Zhejiang 318000, Peoples R China 4.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yu-Fei,Zhao, Ze-Yu,Yang, Min-Jie,et al. Pentacyclic triterpenoids as potential ACL inhibitors from the rare medicinal plant Semiliquidambar cathayensis[J]. FITOTERAPIA,2024,176:10. |
| APA | Wu, Yu-Fei.,Zhao, Ze-Yu.,Yang, Min-Jie.,He, Yu-Hang.,Zang, Yi.,...&Xiong, Juan.(2024).Pentacyclic triterpenoids as potential ACL inhibitors from the rare medicinal plant Semiliquidambar cathayensis.FITOTERAPIA,176,10. |
| MLA | Wu, Yu-Fei,et al."Pentacyclic triterpenoids as potential ACL inhibitors from the rare medicinal plant Semiliquidambar cathayensis".FITOTERAPIA 176(2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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