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Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica

文献类型：期刊论文

作者Wang, Min4,5,6; Li, Han2,3; Hu, Bintao5,6; Tang, Chunping5,6; Xu, Hui2; Ke, Changqiang5,6; Xie, Zuoquan2; Ye, Yang3,4,5,6; Yao, Sheng1,4,5,6
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2024-06-01
卷号22期号:6页码:568-576
关键词Vernonia sylvatica Germacrane-type sesquiterpene lactone Sylvaticalides A-H Anti-inflammatory NF-kappa B path- way ISG pathway
ISSN号2095-6975
DOI10.1016/S1875-5364(24)60656-4
通讯作者Xie, Zuoquan(zqxie@simm.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn) ; Yao, Sheng(yaosheng@simm.ac.cn)
英文摘要Nine new germacranolides, sylvaticalides A-H (1-9), 1 - 9 ), and three known analogues ( 10-12 ) were isolated from the aerial part of Vernonia sylvatica. . Their structures were established using comprehensive spectroscopic analysis, including high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) spectra. Their absolute configurations were determined by X-ray diffraction experiments. The anti-inflammatory activities of all isolated compounds were assessed by evaluating their inhibitory effects on the nuclear factor kappa B (NF-kappa B) pathway, which was activated by lipopolysaccharide (LPS)-stimulated human THP1-Dual cells, and the interferon-stimulated gene (ISG) pathway, activated by STING agonist MSA-2 in the same cell model. Compounds 1 , 2 and 6 showed inhibitory effects on the NF-kappa B and ISG signaling pathways, with IC50 50 values ranging from 4.12 to 10.57 mu molL-1. -1 .
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001293870700001
出版者CHINESE JOURNAL NATURAL MEDICINES
源URL[http://119.78.100.183/handle/2S10ELR8/312833]  
专题新药研究国家重点实验室
通讯作者Xie, Zuoquan; Ye, Yang; Yao, Sheng
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Min,Li, Han,Hu, Bintao,et al. Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(6):568-576.
APA Wang, Min.,Li, Han.,Hu, Bintao.,Tang, Chunping.,Xu, Hui.,...&Yao, Sheng.(2024).Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica.CHINESE JOURNAL OF NATURAL MEDICINES,22(6),568-576.
MLA Wang, Min,et al."Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica".CHINESE JOURNAL OF NATURAL MEDICINES 22.6(2024):568-576.

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来源：上海药物研究所

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