Atrazine-Induced Toxicity and Biochemical Changes in Mus musculus: the Ameliorative Efficacy of Nigella sativa L. (Ranunculaceae) Oil
文献类型：期刊论文
| 作者 | Malik, Sumera Yasmeen12; Arshad, Muhammad12; Batool, Sajida12; Batool, Saira12; Iram, Fatima12; Batool, Tahira11; Ali, Baber10; Wahab, Sana; Khan, Muhammad Nauman9; Kaplan, Alevcan8 |
| 刊名 | POLISH JOURNAL OF ENVIRONMENTAL STUDIES
 |
| 出版日期 | 2024 |
| 卷号 | 33期号:5页码:5211-5220 |
| 关键词 | Nigella sativa oil atrazine mice hematological parameters liver function test kidney function test black seed oil |
| ISSN号 | 1230-1485 |
| DOI | 10.15244/pjoes/183076 |
| 英文摘要 | The study aimed to evaluate the ameliorative potential of Nigella sativa oil (N.s) against the adverse effects induced by atrazine (ATZ) in mice. Four groups were divided into: Control group (untreated); N.s group ( N. sativa oil, 2 mL/kg/BW); ATZ group (atrazine 200 mg/kg/BW); ATZ+N.s group (atrazine 200 mL/kg/BW; and N. sativa oil, 2 mL/kg/BW). All doses were administered by gavage once daily for 4 weeks. The atrazine-administered group showed a significant increase in total leukocytes, granulocytes, and agranulocytes and a decrease in red blood cells, hemoglobin, mean corpuscular volume, and packed cell volume. Serum concentrations of aspartate aminotransferase, alanine transaminase, and alkaline phosphatase were high in the ATZ group. Atrazine exposure reduced serum albumin and total protein levels in the blood. A significantly higher concentration of bilirubin, urea, and creatinine was also found in the ATZ group. The simultaneous administration of atrazine and N. sativa led to improvements in all the parameters studied above. Thus, this study revealed that atrazine exposure has toxic effects on hematological parameters, liver, and kidney function, and that N. sativa oil reduces these toxic effects of atrazine in male mice. |
| WOS关键词 | OXIDATIVE STRESS ; LIVER ; EXTRACTS ; ENZYMES ; KIDNEY ; DAMAGE ; SEEDS |
| 资助项目 | Deputyship for Research and Innovation Ministry of Education In Saudi Arabia[IFKSUOR3-413-1] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001260338900017 |
| 出版者 | HARD |
| 资助机构 | Deputyship for Research and Innovation Ministry of Education In Saudi Arabia |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/207797]  |
| 专题 | 生态系统网络观测与模拟院重点实验室_外文论文 |
| 通讯作者 | Batool, Sajida; Khan, Muhammad Nauman |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Ecosyst Network Observat & Modeling, Inst Geog Sci & Nat Resources Res, 11A Datun Road, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci UCAS, Beijing 100049, Peoples R China 3.HGF Agro, Ata Teknokent, TR-25240 Erzurum, Turkiye 4.Ataturk Univ, Dept Hort, Fac Agr, TR-25240 Erzurum, Turkiye 5.King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia 6.King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia 7.Univ Malakand, Dept Biotechnol, Khyber Pakhtunkhwa 18800, Pakistan 8.Batman Univ, Sason Vocat Sch, Dept Crop & Anim Prod, Batman, Turkiye 9.Islamia Coll Peshawar, Dept Bot, Peshawar 25120, Pakistan 10.Quaid I Azam Univ, Dept Plant Sci, Islamabad 45320, Pakistan |
| 推荐引用方式 GB/T 7714 | Malik, Sumera Yasmeen,Arshad, Muhammad,Batool, Sajida,et al. Atrazine-Induced Toxicity and Biochemical Changes in Mus musculus: the Ameliorative Efficacy of Nigella sativa L. (Ranunculaceae) Oil[J]. POLISH JOURNAL OF ENVIRONMENTAL STUDIES,2024,33(5):5211-5220. |
| APA | Malik, Sumera Yasmeen.,Arshad, Muhammad.,Batool, Sajida.,Batool, Saira.,Iram, Fatima.,...&Iqbal, Majid.(2024).Atrazine-Induced Toxicity and Biochemical Changes in Mus musculus: the Ameliorative Efficacy of Nigella sativa L. (Ranunculaceae) Oil.POLISH JOURNAL OF ENVIRONMENTAL STUDIES,33(5),5211-5220. |
| MLA | Malik, Sumera Yasmeen,et al."Atrazine-Induced Toxicity and Biochemical Changes in Mus musculus: the Ameliorative Efficacy of Nigella sativa L. (Ranunculaceae) Oil".POLISH JOURNAL OF ENVIRONMENTAL STUDIES 33.5(2024):5211-5220. |
入库方式： OAI收割
来源：地理科学与资源研究所
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