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Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study

文献类型：期刊论文

作者Li, Deyang3,4; Li, Xingxing1,2,3,4; Li, Jiaxin3,4; Liu, Junyao3,4; Luo, Ruichenxi3,4; Li, Yanli3,4; Wang, Dongmei3,4; Zhou, Dongsheng1,2; Zhang, Xiang-Yang3,4
刊名INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
出版日期2024-07-01
卷号24期号:3页码:8
关键词TMS-EEG Major depressive disorder Dorsolateral prefrontal cortex Cognitive function Biomarker
ISSN号1697-2600
DOI10.1016/j.ijchp.2024.100495
通讯作者Wang, Dongmei(wangdm@psych.ac.cn) ; Zhou, Dongsheng(wyzhouds@sina.com) ; Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要Background: Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a powerful technique to study the neuropathology and biomarkers of major depressive disorder (MDD). This study investigated cortical activity and its relationship with clinical symptoms and cognitive dysfunction in MDD patients by indexing TMSEEG biomarkers in the dorsolateral prefrontal cortex (DLPFC). Methods: 133 patients with MDD and 76 healthy individuals participated in this study. Single-pulse TMS was performed on the left DLPFC to obtain TMS-evoked potential (TEP) indices. TMS-EEG waveforms and components were determined by global mean field amplitude. We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to measure participants' cognitive function. Results: Patients with MDD had a lower excitatory P180 index compared to healthy controls, and P180 amplitude was negatively correlated with the severity of depressive and anxiety symptoms in patients with MDD. In the MDD group, P30 amplitude was negatively associated with RBANS Visuospatial/ Constructional index and total score. Conclusions: TMS-EEG findings suggest that abnormal cortical excitation and inhibition induced by TMS on the DLPFC are associated with the severity of clinical symptoms and cognitive dysfunction in patients with MDD. P180 and P30 have the potential to serve as neurophysiological biomarkers of clinical symptoms and cognitive dysfunction in MDD patients, respectively.
收录类别SCI
WOS关键词TRANSCRANIAL MAGNETIC STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; BRAIN CONNECTIVITY ; NEUROTRANSMISSION ; EXCITABILITY ; SINGLE ; DRUGS ; EMG
资助项目STI2030-Major Projects[2021ZD0202102] ; Basic Public Welfare Project of Zhejiang Province[LGF22H090055] ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2019RC079] ; CAS Key Lab of Mental Health
WOS研究方向Psychology
语种英语
WOS记录号WOS:001311484900001
出版者ELSEVIER SCIENCE INC
资助机构STI2030-Major Projects ; Basic Public Welfare Project of Zhejiang Province ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission ; CAS Key Lab of Mental Health
源URL[http://ir.psych.ac.cn/handle/311026/48897]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Dongmei; Zhou, Dongsheng; Zhang, Xiang-Yang
作者单位1.Ningbo Kangning Hosp, Dept Psychiat, Ningbo, Zhejiang, Peoples R China
2.Ningbo Univ, Affiliated Kangning Hosp, Dept Psychiat, Ningbo 315201, Zhejiang, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Deyang,Li, Xingxing,Li, Jiaxin,et al. Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2024,24(3):8.
APA Li, Deyang.,Li, Xingxing.,Li, Jiaxin.,Liu, Junyao.,Luo, Ruichenxi.,...&Zhang, Xiang-Yang.(2024).Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,24(3),8.
MLA Li, Deyang,et al."Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 24.3(2024):8.

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来源：心理研究所

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