Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression
文献类型：期刊论文
| 作者 | Sun, Qixuan4,5; Ding, Haiyang2,3,5; Lu, Chenxuan5; Yan, Lailai1; Cao, Bing5 |
| 刊名 | FRONTIERS IN PUBLIC HEALTH
 |
| 出版日期 | 2024-08-29 |
| 卷号 | 12页码:11 |
| 关键词 | case-control experiment environmental metal major depressive disorder serum urinary |
| DOI | 10.3389/fpubh.2024.1450983 |
| 通讯作者 | Yan, Lailai(yll@bjmu.edu.cn) ; Cao, Bing(bingcao@swu.edu.cn) |
| 英文摘要 | Background: Major depressive disorder (MDD) is a prevalent mental disorder globally. Increasing evidence suggests that Environmental Metal (EM) play a crucial role in MDD. Therefore, this study investigated the roles of barium (Ba), cesium (Cs), nickel (Ni), manganese (Mn), lead (Pb), mercury (Hg), cadmium (Cd), and tin (Sn) in the etiology of MDD. Methods: The study included 72 MDD patients and 75 healthy controls (HCs) from the Second People's Hospital of Zhumadian, China. Inductively coupled plasma mass spectrometer (ICP-MS) measured the metal levels in serum and urine samples from both groups. Results: Significant differences in serum and urine levels of EMs were observed between MDD patients and HCs. After adjusting for age, gender, and BMI, logistic regression and quantile regression models revealed significant associations between EMs and MDD. In serum samples, higher Sn levels (OR = 1.22, p = 0.044) increased MDD risk, whereas higher Cs levels (OR = 0.02, p < 0.001), Cd (OR = 0.06, p = 0.047), and Mn (OR = 0.54, p = 0.016) decreased MDD risk. In urine samples, higher Ba levels (OR = 0.94, p = 0.015), Ni (OR = 0.87, p = 0.0024), Sn (OR = 1.62, p < 0.001), and Mn (OR = 0.77, p = 0.037) were significantly associated with MDD. Sn significantly positively predicted HAMD-24 scores at the 0.50 and 0.75 quantiles (beta = 0.96, p = 0.018; beta = 1.25, p = 0.008) as did Pb (beta = 5.15, p = 0.001; beta = 4.19, p = 0.004). Ba positively predicted depressive symptoms across all quantiles (all p < 0.05). Hg positively predicted HAMD-24 scores at the 0.50 quantile (beta = 9.20, p = 0.050). Conclusion: These findings underscore EMs' importance in depression, aiding in targeted interventions for varying degrees of depression and necessitating future studies to clarify causality and mechanisms. |
| 收录类别 | SCI |
| WOS关键词 | BLOOD ; ANXIETY ; ADULTS |
| WOS研究方向 | Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:001310346100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48900]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Yan, Lailai; Cao, Bing |
| 作者单位 | 1.Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Southwest Univ, Coll Comp & Informat Sci, Chongqing, Peoples R China 5.Southwest Univ, Minist Educ, Fac Psychol, Key Lab Cognit & Personal, Chongqing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Qixuan,Ding, Haiyang,Lu, Chenxuan,et al. Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression[J]. FRONTIERS IN PUBLIC HEALTH,2024,12:11. |
| APA | Sun, Qixuan,Ding, Haiyang,Lu, Chenxuan,Yan, Lailai,&Cao, Bing.(2024).Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression.FRONTIERS IN PUBLIC HEALTH,12,11. |
| MLA | Sun, Qixuan,et al."Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression".FRONTIERS IN PUBLIC HEALTH 12(2024):11. |
入库方式： OAI收割
来源：心理研究所
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