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Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project

文献类型：期刊论文

作者Zhang, Zhenqing4,5; Huang, Bingjie4; Wu, Weiwei4,5; Ye, Xiaobin3; Gao, Tianqi4; Guo, Xiaodong4; Yu, Xin4; Wang, Yi1,2; Pu, Chengcheng4
刊名ASIAN JOURNAL OF PSYCHIATRY
出版日期2024-11-01
卷号101页码:8
关键词First-episode schizophrenia Negative symptoms Neurocognitive symptoms Network analysis
ISSN号1876-2018
DOI10.1016/j.ajp.2024.104202
通讯作者Wang, Yi(wangyi@psych.ac.cn) ; Pu, Chengcheng(puchengcheng@bjmu.edu.cn)
英文摘要Background: Schizophrenia is a heterogeneous psychotic disorder. Recent theories have emphasized the importance of interactions among psychiatric symptoms in understanding the pathological mechanisms of schizophrenia. In the current study, we examined the symptom network in patients with first-episode schizophrenia (FES) at four time points during a six-month follow-up period. Methods: In total, 565 patients with FES were recruited from the Chinese First-Episode Schizophrenia Trial (CNFEST) project. Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up (514 patients at one month, 429 at three months, and 392 at six months). We used a network analysis approach to estimate symptom networks with individual symptoms as nodes and partial correlation coefficients between symptoms as edges. A cross-lagged panel network (CLPN) model was used to identify predictive pathways for clinical symptoms. Results: We found stable and strongly connected edges in patients across the time points, such as links between delusions and suspiciousness/persecution (P1:P6), and emotional withdrawal and passive/apathetic social withdrawal (N2:N4). Emotional withdrawal (N2), poor rapport (N3), and passive/apathetic social withdrawal (N4) had high centrality estimates across all four time points. CLPN analysis showed that negative symptoms, including emotional withdrawal (N2), poor rapport (N3), and passive/apathetic social withdrawal (N4), and stereotyped thinking (N7) may have predictive effects for negative and general symptoms at follow-ups. Conclusions: The symptom network of schizophrenia may be dynamic as treatment progresses. Negative symptoms remain the central and stable symptoms of schizophrenia. Negative symptoms may be potential therapeutic targets that predict other symptoms.
收录类别SCI
WOS关键词NEGATIVE SYMPTOMS ; PREDICTORS ; SCALE
资助项目Xiamen Xianyue Hospital Foundation[2020XYYB05] ; National Science Fund China[82171500] ; Key Program of Beijing Science and Technology Commission[D171100007017002] ; Capital's Funds for Health Improvement and Research (CFH)[2018-4-4116] ; National Natural Science Foundation of China[31871114] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001311808700001
出版者ELSEVIER
资助机构Xiamen Xianyue Hospital Foundation ; National Science Fund China ; Key Program of Beijing Science and Technology Commission ; Capital's Funds for Health Improvement and Research (CFH) ; National Natural Science Foundation of China ; CAS Key Laboratory of Mental Health, Institute of Psychology
源URL[http://ir.psych.ac.cn/handle/311026/48930]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Yi; Pu, Chengcheng
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
3.Zhangzhou Fourth Hosp, Zhangzhou, Fujian, Peoples R China
4.Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental D, Beijing, Peoples R China
5.Xiamen Xianyue Hosp, Xianyue Hosp, Fujian Psychiat Ctr, Fujian Clin Res Ctr Mental Disorders,Xiamen Med Co, Xiamen, Fujian, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zhenqing,Huang, Bingjie,Wu, Weiwei,et al. Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project[J]. ASIAN JOURNAL OF PSYCHIATRY,2024,101:8.
APA Zhang, Zhenqing.,Huang, Bingjie.,Wu, Weiwei.,Ye, Xiaobin.,Gao, Tianqi.,...&Pu, Chengcheng.(2024).Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project.ASIAN JOURNAL OF PSYCHIATRY,101,8.
MLA Zhang, Zhenqing,et al."Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project".ASIAN JOURNAL OF PSYCHIATRY 101(2024):8.

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来源：心理研究所

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