The oxytocinergic system and racial ingroup bias in empathic neural activity
文献类型：期刊论文
| 作者 | Duan, Qin3; Fan, Leyi3; Zhou, Yuqing2 ; Luo, Siyang3; Han, Shihui1
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| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2024-12-15 |
| 卷号 | 261页码:10 |
| 关键词 | Racial ingroup bias in empathy Oxytocin receptor gene Oxytocin Dynamic causal modeling fMRI |
| ISSN号 | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2024.110151 |
| 通讯作者 | Luo, Siyang(Luosy6@mail.sysu.edu.cn) ; Han, Shihui(shan@pku.edu.cn) |
| 英文摘要 | Studies have indicated that the human brain exhibits a more robust neural empathic response towards individuals of the same racial ingroup than those of the outgroup. However, the impact of the oxytocinergic system on the dynamic connectivity between brain regions involved in racial ingroup bias in empathy (RIBE) and its implications for real-life social interaction intention remains unclear. To address this gap, we employed functional magnetic resonance imaging (fMRI) to investigate RIBE-modulated neural activities and the influence of the oxytocinergic system at both neural and behavioral levels. Participants homozygous for the A/A and G/G genotypes of the oxytocin receptor gene (OXTR) rs53576 polymorphism underwent scanning while making judgments about painful versus non-painful stimuli in same-race versus other-race scenarios following either oxytocin (OT) or placebo treatment. The results revealed greater activity in the anterior cingulate cortex (ACC) and anterior insula (AI) in response to same-race compared to other-race models in the G/G group but not in the A/A group. RIBE also modulated the connections between bilateral AI and the ACC, and the effect of OT on this modulatory effect was moderated by genotype rs53576 and interpersonal trust. Moreover, more extensive changes in AI-ACC connections were associated with higher levels of revenge intention in the low interpersonal trust group. Overall, our findings suggest a pivotal role of the oxytocinergic system in the RIBE-modulated neural activities and revenge intention in human interactions with the modulatory effect of interpersonal trust. |
| 收录类别 | SCI |
| WOS关键词 | RECEPTOR GENE ; OTHERS PAIN ; RESPONSES ; NETWORKS ; CORTEX ; COMMON |
| 资助项目 | National Natural Science Foundation of China[32071081] ; National Natural Science Foundation of China[32371125] ; National Natural Science Foundation of China[32230043] ; National Natural Science Foundation of China[32371092] ; National Natural Science Foundation of China[91332125] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001313069400001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48911]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Luo, Siyang; Han, Shihui |
| 作者单位 | 1.Peking Univ, PKU IDG McGovern Inst Brain Res, Dept Psychol, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Sun Yat Sen Univ, Dept Psychol, Guangdong Key Lab Social Cognit Neurosci & Mental, Guangdong Prov Key Lab Brain Funct & Dis, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Qin,Fan, Leyi,Zhou, Yuqing,et al. The oxytocinergic system and racial ingroup bias in empathic neural activity[J]. NEUROPHARMACOLOGY,2024,261:10. |
| APA | Duan, Qin,Fan, Leyi,Zhou, Yuqing,Luo, Siyang,&Han, Shihui.(2024).The oxytocinergic system and racial ingroup bias in empathic neural activity.NEUROPHARMACOLOGY,261,10. |
| MLA | Duan, Qin,et al."The oxytocinergic system and racial ingroup bias in empathic neural activity".NEUROPHARMACOLOGY 261(2024):10. |
入库方式： OAI收割
来源：心理研究所
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