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Elevated VCAM-1 levels in peripheral blood are associated with brain structural and functional alterations in major depressive disorder

文献类型：期刊论文

作者Zhou, Jingjing3,4,5; Liu, Rui3,4,5; Zhou, Jia3,4,5; Liu, Jing3,4,5; Zhou, Yuan1,2,3,4,5; Yang, Jian3,4,5; Wang, Gang3,4,5
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2024-02-15
卷号347页码:584-590
关键词Major depressive disorder Vascular cell adhesion molecule-1 Gray matter volume Functional connectivity
ISSN号0165-0327
DOI10.1016/j.jad.2023.12.001
通讯作者Yang, Jian(yangjian@ccmu.edu.cn) ; Wang, Gang(gangwangdoc@ccmu.edu.cn)
英文摘要Background: Vascular cell adhesion molecule-1 (VCAM-1) is a well-known biomarker of endothelial activation. This study aimed to determine whether changes in peripheral VCAM-1 levels occurred in major depressive disorder (MDD) patients and explored immune-brain interactions based on neuroimaging. Methods: This study included 165 subjects (80 healthy controls [HCs] and 85 MDD patients). Of them, 133 underwent magnetic resonance imaging. VCAM-1 was measured using a commercially available Enzyme-Linked Immunosorbent Assay kit following the manufacturer's instructions. The gray matter volume (GMV) and surface- based functional connectivity (FC) were calculated based on Schaefer parcellation 400 parcels. Results: Compared with the HCs, MDD patients exhibited significantly higher level of VCAM-1. The correlation analysis showed that VCAM-1 had a significant negative correlation with GMV of the right medial frontal cortex (MFC) and postcentral (PostCG). The mediation analyses showed that VCAM-1 mediated the association between group and GMV of PostCG and the FC of left ventral prefrontal cortex (vPFC) with right inferior parietal lobe (IPL). Conclusions: This study showed that a high level of VCAM-1 was associated to the decreased GMV in the right MFC and PostCG, and mediated the FC of the left vPFC with right IPL. These findings suggested that VCAM-1 might contribute to the etiology of MDD by influencing brain structure and function. Limitations: The cross-sectional design makes it difficult to determine the causal relationship and dynamic effect among VCAM-1, brain structure/function features, and depressive symptoms.
收录类别SCI
WOS关键词NF-KAPPA-B ; LOW-GRADE INFLAMMATION ; MEDIAL FRONTAL-CORTEX ; ENDOTHELIAL DYSFUNCTION ; CARDIOVASCULAR-DISEASE ; PREFRONTAL CORTEX ; VASCULAR-DISEASE ; EXPRESSION ; CONNECTIVITY ; ACTIVATION
资助项目STI2030-Major Projects[2021ZD0200600] ; High Level Public Health Technical Talents Construction Project[02-39] ; Capital's Funds for Health Improvement and Research[CFH2020-4-2125] ; Beijing Hospitals Authority Youth Programme[QMS20191904] ; Beijing Hospitals Authority Youth Programme[QML20211901] ; Beijing Talents Project[2020A38] ; Beijing Young Top-Notch Talent Support project[2018000021223ZK36]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001299327900001
出版者ELSEVIER
资助机构STI2030-Major Projects ; High Level Public Health Technical Talents Construction Project ; Capital's Funds for Health Improvement and Research ; Beijing Hospitals Authority Youth Programme ; Beijing Talents Project ; Beijing Young Top-Notch Talent Support project
源URL[http://ir.psych.ac.cn/handle/311026/48833]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Yang, Jian; Wang, Gang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
5.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Jingjing,Liu, Rui,Zhou, Jia,et al. Elevated VCAM-1 levels in peripheral blood are associated with brain structural and functional alterations in major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,347:584-590.
APA Zhou, Jingjing.,Liu, Rui.,Zhou, Jia.,Liu, Jing.,Zhou, Yuan.,...&Wang, Gang.(2024).Elevated VCAM-1 levels in peripheral blood are associated with brain structural and functional alterations in major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,347,584-590.
MLA Zhou, Jingjing,et al."Elevated VCAM-1 levels in peripheral blood are associated with brain structural and functional alterations in major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 347(2024):584-590.

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来源：心理研究所

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