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Characterizing human spontaneous thoughts and its application in major depressive disorder

文献类型：期刊论文

作者Li, Hui-Xian6,7; Chen, Xiao5,6; Wang, Zi-Han5,6; Lu, Bin5,6; Liao, Yi-Fan5,6; Li, Xue-Ying5,6; Wang, Yu-Wei5,6; Liu, Yan-Song4; Castellanos, Francisco Xavier2,3; Yan, Chao-Gan1,5,6
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2024-11-15
卷号365页码:276-284
关键词Depression Sex differences Resting-state spontaneous thought Think-aloud method Natural language processing
ISSN号0165-0327
DOI10.1016/j.jad.2024.08.060
通讯作者Yan, Chao-Gan(yancg@psych.ac.cn)
英文摘要Background: Spontaneous thought is a universal, complex, and heterogeneous cognitive activity that significantly impacts mental activity and strongly correlates with mental disorders. Methods: Utilizing the think-aloud method, we captured spontaneous thoughts during rest from 38 diagnosed with depression, alongside 36 healthy controls and 137 healthy individuals. Through a comprehensive assessment of various dimensions of thought content, we compared thought content between individuals with depression and healthy controls, and between healthy women and men. Finally, we employed natural language processing (NLP) to develop regression models for multidimensional content assessment and a classification model to differentiate between individuals with and without depression. Results: Compared to healthy controls, individuals with depression had more internally oriented and less externally oriented spontaneous thoughts. They focused more on themselves and negative things, and less on positive things, experiencing higher levels of negative emotions and lower levels of positive emotions. Besides, we found that compared to healthy men, healthy women's spontaneous thoughts focus more on interoception, the self, past events, and negative events, and they experience higher levels of negative emotions. Meanwhile, we identified the potential application of the think-aloud method to collect spontaneous thoughts and integrate NLP in the field of depression. Conclusions: This study offers direct insights into the stream of thought during individuals' resting state, revealing differences between individuals with depression and healthy controls, as well as sex differences in the content of spontaneous thoughts. It enhances our understanding of spontaneous thought and offers a new perspective for preventing, diagnosing, and treating depression.
收录类别SCI
WOS关键词MIND WANDERS ; SEX-DIFFERENCES ; TIME
资助项目Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology[2021ZD0200600] ; National Key Research and Development Program of China[2017YFC1309902] ; National Natural Science Foundation of China[82122035] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[32300933] ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Beijing Nova Program of Science and Technology[20230484465] ; Beijing Natural Science Foundation[J230040] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4425YZ] ; Postdoctoral Research Special Fund of the Third Affiliated Hospital of Zhengzhou University[2023080] ; China Scholarship Council (CSC)[202104910248]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001301248600001
出版者ELSEVIER
资助机构Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Beijing Natural Science Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Postdoctoral Research Special Fund of the Third Affiliated Hospital of Zhengzhou University ; China Scholarship Council (CSC)
源URL[http://ir.psych.ac.cn/handle/311026/48841]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Yan, Chao-Gan
作者单位1.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
2.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
3.NYU, Robert I Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA
4.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China
5.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China
6.Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
7.Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hui-Xian,Chen, Xiao,Wang, Zi-Han,et al. Characterizing human spontaneous thoughts and its application in major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,365:276-284.
APA Li, Hui-Xian.,Chen, Xiao.,Wang, Zi-Han.,Lu, Bin.,Liao, Yi-Fan.,...&Yan, Chao-Gan.(2024).Characterizing human spontaneous thoughts and its application in major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,365,276-284.
MLA Li, Hui-Xian,et al."Characterizing human spontaneous thoughts and its application in major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 365(2024):276-284.

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来源：心理研究所

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