Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer
文献类型：期刊论文
| 作者 | Zhang, Huijuan5,6,7; Chen, Fangmin4,5,6; Cheng, Wenhao5,6; Lai, Yi5,6; Hou, Bo5,6; Shan, Yiming4,5,6; Qu, Xiongwei7; Xu, Zhi Ping2,3; Xu, Zhiai1; Hu, Xiuli7 |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 58页码:12 |
| 关键词 | Polyphenol Cuproptosis Dynamic covalent bond Cancer metalloimmunotherapy Tumor immune microenvironment |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2024.102442 |
| 通讯作者 | Qu, Xiongwei(xwqu@hebut.edu.cn) ; Hu, Xiuli(huxiuli@hebut.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Polyphenolic materials have been extensively explored for biomedical applications. However, most polymerbased polyphenols are synthesized by covalently grafting phenol groups on the backbone of polymers and more convenient synthetic strategy remains challenging. Herein, a general and robust strategy to synthesize polypeptide-based polyphenol via selective ortho-hydroxylation of poly(tyrosine) was developed to construct dynamic nanoparticles (GPCuD NPs) composed of Cu2+ and phenylboronic acid modified doxorubicin prodrug (DOX-PBA) via metal-phenol coordination interaction and pH-reversible phenylboronate ester bond, respectively. Furthermore, matrix metalloproteinase-2 (MMP-2)-cleavable GPLGLAG peptide was also included between the polyethylene glycol and polyphenol segments, endowing GPCuD NPs with tumor-specific accumulation and deep penetration through enzyme-triggered depegylation. Notably, Cu2+-chelated nanoparticles efficiently ameliorated the immunosuppressive tumor microenvironment via recruiting antitumor immune cells and repolarizing M2-type tumor-associated macrophages to M1 phenotype. The combination of cuproptosis-driven metalloimmunotherapy with DOX chemotherapy remarkably suppressed 4T1 orthotopic breast tumor growth by 81.9 % and established a long-term immune memory (effective memory T cells up to 30.8 %) to prevent lung metastasis. This study has demonstrated a generalizable polyphenol nanoplatform for tumor-targeted and cuproptosis-regulated combination cancer metalloimmunotherapy. |
| WOS关键词 | IMMUNE RESISTANCE ; CHEMOTHERAPY |
| 资助项目 | National Natural Science Foundation of China[U22A20328] ; National Natural Science Foundation of China[51973213] ; National Natural Science Foundation of China[23490712700] ; Government Guide the Development of Local Science and Technology Special Funds[226Z1203G] ; Science and Technology Commission of Shanghai Mu-nicipality[23ZR1475000] ; Science and Technology Commission of Shanghai Mu-nicipality[20430711800] ; State Key Laboratory of Chemical Biology ; National Facility for Protein Science in Shanghai (NFPS) , Shanghai Advanced Research Institute, CAS ; Shanghai Institute of Materia Medica, CAS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001297709200001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312890]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qu, Xiongwei; Hu, Xiuli; Yu, Haijun |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Inst Syst & Phys Biol, Shenzhen Bay Lab, Shenzhen 518067, Peoples R China 3.Inst Biomed Hlth Technol & Engn, Shenzhen 518067, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 7.Hebei Univ Technol, Inst Polymer Sci & Engn, Sch Chem Engn, Tianjin 300130, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Huijuan,Chen, Fangmin,Cheng, Wenhao,et al. Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer[J]. NANO TODAY,2024,58:12. |
| APA | Zhang, Huijuan.,Chen, Fangmin.,Cheng, Wenhao.,Lai, Yi.,Hou, Bo.,...&Yu, Haijun.(2024).Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer.NANO TODAY,58,12. |
| MLA | Zhang, Huijuan,et al."Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer".NANO TODAY 58(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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